| Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. | |
| | |
MedLine Citation:
|
PMID: 2829279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a 24 h kinetic study docosahexaenoic acid (DCHA, C22:6n-3) or eicosapentaenoic acid (EPA, C20:5n-3) were given in a single dose to healthy male volunteers. PGI3-M, the main urinary metabolite of prostaglandin I3 was below the detection limit in the control periods, but was excreted already in the first 4 h after ingestion of DCHA or EPA and decreased thereafter. Excretion of PGI2-M did not change significantly. In a second dietary trial DCHA and EPA were given cross-over to 7 healthy male volunteers for 6 days. PGI3-M was formed after DCHA and EPA in amounts of 35 and 20% of PGI2-M and showed a considerable interindividual variation. The structure of PGI3-M was verified by independent biochemical synthesis. Our data indicate that dietary DCHA is retroconverted to EPA in man, which is quickly transformed--like dietary EPA itself--to prostaglandin I3. DCHA may therefore serve as a precursor fatty acid for EPA and its cyclooxygenated and lipoxygenated products. |
| | |
Authors:
|
S Fischer; A Vischer; V Preac-Mursic; P C Weber |
Related Documents
:
|
12837849 - Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress,... 8541279 - Impact of polyunsaturated fatty acids on human colonic bacterial metabolism: an in vitr... 20074389 - Effect of dietary fatty acid intake on prospective weight change in the heidelberg coho... 11035829 - Effects of long-chain polyunsaturated fatty acid supplementation on fatty acid status a... 16809099 - Polyunsaturated fatty acids: biotechnology. 10189709 - Cloning and characterization of a seed-specific omega-3 fatty acid desaturase cdna from... 15741159 - Role of regulatory f-domain in hepatocyte nuclear factor-4alpha ligand specificity. 6465549 - Studies on the male antifertility agent gossypol acetic acid. vi. effect of gossypol ac... 4061889 - Ion-exchange chromatography of amino acids in ejaculates of diabetics. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Prostaglandins Volume: 34 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1987 Sep |
Date Detail:
|
Created Date: 1988-02-26 Completed Date: 1988-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 367-75 Citation Subset: IM |
Affiliation:
|
Medizinische Universitätsklinik Innenstadt, München, F.R.G. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / metabolism Cattle Dietary Fats / metabolism* Docosahexaenoic Acids / metabolism*, urine Eicosapentaenoic Acid / biosynthesis*, urine Epoprostenol / biosynthesis* Humans Kinetics Male Mass Spectrometry |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 35121-78-9/Epoprostenol; 68794-57-0/prostaglandin I3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of Junin virus from blood and peripheral lymphocytes of infected Calomys musculinus
Next Document: The metabolism of synthetic leukotriene B4 in synovial fluid and whole human blood.