| Dietary docosahexaenoic acid [22: 6(n-3)] as a phospholipid or a triglyceride enhances the potassium chloride-evoked release of acetylcholine in rat hippocampus. | |
| | |
MedLine Citation:
|
PMID: 15867273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We demonstrated previously that a dietary-induced depletion of docosahexaenoic acid (DHA) in cerebral phospholipids increases the spontaneous release of acetylcholine (Ach) in the rat hippocampus and reduces its potassium chloride evoked-release. In the present study, we investigated the effects in rats of DHA-enriched diets supplied by egg phospholipids (E-PL) or tuna oil (TO) on the PUFA in hippocampus membranes and on the synaptic release of Ach. Control rats were fed 3 g/kg of the DHA precursor, alpha-linolenic acid (LNA). Chronically (n-3) PUFA-deficient females were fed, starting 2 wk before mating, the deficient diet, a control diet, or a purified diet supplying 1, 2, or 3 g DHA/kg diet as E-PL or TO. Experiments were performed on the adult male progeny fed the same diet as their dams throughout life. The form of dietary DHA (TO or E-PL) did not influence its incorporation into the hippocampus. The 1 g DHA/kg diets allowed maximal incorporation into phosphatidylethanolamine (PE), but 2 g DHA/kg diet was needed for phosphatidylcholine (PC). A minimum of 2 g DHA/kg was needed to decrease the basal Ach release and to enhance the stimulated release to that of the control; the Ach release of the 1 g/kg DHA-groups did not differ from that of the deficient group. This suggests that >1 g DHA/kg diet is needed to ensure PUFA incorporation into PE and PC, and basal and stimulated Ach release in the rat hippocampus equivalent to the control group fed only LNA. PUFA incorporation into the hippocampus depends mainly on the PUFA concentration of the diet, not on the form of dietary DHA. |
| | |
Authors:
|
S Aïd; S Vancassel; A Linard; M Lavialle; P Guesnet |
Related Documents
:
|
3856283 - Plasma essential fatty acids in pure and mixed race american indians on and off a diet ... 15522133 - Dietary n-6:n-3 fatty acid ratio in the perinatal period affects bone parameters in adu... 19798073 - The effect of mannan oligosaccharide supplementation on body weight gain and fat accrua... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of nutrition Volume: 135 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-05-03 Completed Date: 2005-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1008-13 Citation Subset: IM |
Affiliation:
|
INRA, Laboratoire de Nutrition et Sécurité Alimentaire, Jouy-en-Josas, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
secretion* Administration, Oral Animals Body Weight / drug effects Docosahexaenoic Acids / administration & dosage, pharmacology* Eggs Fatty Acids, Omega-3 / pharmacology* Female Fish Oils / pharmacology Hippocampus / drug effects, physiology* Lactation / drug effects, physiology Phospholipids / pharmacology* Plant Oils Potassium Chloride / pharmacology* Rats Triglycerides / pharmacology* Tuna |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 0/Plant Oils; 0/Triglycerides; 25167-62-8/Docosahexaenoic Acids; 51-84-3/Acetylcholine; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased Zn...
Next Document: Human cortical specialization for food: a functional magnetic resonance imaging investigation.