| Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats. | |
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MedLine Citation:
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PMID: 12550065 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have recently shown that the long-term ingestion of dietary diacylglycerol (DAG) mainly containing 1,3-isoform reduces body fat accumulation in humans as compared to triacylglycerol (TAG) with the same fatty acid composition. The fat reduction in this human experiment was most pronounced in visceral fat and hepatic fat. Recent animal studies have also indicated that dietary DAG induces alteration of lipid metabolism in the rat liver. In the present study, the dietary effects of DAG on high fat diet-induced hepatic fat accumulation and hepatic microsomal triglyceride transfer protein (MTP) activity were examined in comparison with those of TAG diet in rats. When the TAG oil content was increased from 10 to 30 g/100 g diet, hepatic TAG concentration, hepatic MTP activity and MTP large subunit mRNA levels were significantly increased after 21 days. However, when the dietary TAG oil (30 g/100 g diet) was replaced with the same concentration of DAG oil with the same fatty acid composition, the increase of the TAG concentration and the MTP activity in the liver were significantly less and the mRNA levels remained unchanged. The MTP activity levels correlated significantly with hepatic TAG concentration.These results showed that dietary DAG may suppress high fat diet-induced MTP activity in the liver, and indicated the possibility that hepatic TAG concentration may regulate hepatic MTP activity. |
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Authors:
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Hiroyuki Taguchi; Toshiko Omachi; Tomonori Nagao; Noboru Matsuo; Ichiro Tokimitsu; Hiroshige Itakura |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 13 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2003-Jan-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: - |
Other Details:
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Languages: ENG Pagination: 678-683 Citation Subset: - |
Affiliation:
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Biological Science Laboratories, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, 321-3497, Tochigi, Japan |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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