Document Detail


Dietary determinants of plasma enterolactone.
MedLine Citation:
PMID:  11815409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Enterolactone is a lignan produced by fermentation of dietary precursors in the human gut. Because lignan precursors are uniquely found in plant foods, plasma enterolactone concentration may serve as a biological marker of plant food consumption. This cross-sectional study examined associations of dietary intake with plasma enterolactone concentration. Weight-stable, 20-40-year-old volunteers (115 women and 78 men in Seattle, Washington) reporting intake of < or =2.5 or > or =4.5 fruit and vegetable servings/day and no antibiotic use for > or =3 months completed a food frequency questionnaire and 3-day food record. Time-resolved fluoroimmunoassay was used to measure plasma enterolactone. Based on diet records, plasma enterolactone was positively correlated with daily vegetable servings (r = 0.17; P < 0.05), fiber (r = 0.36; P < 0.0001), alcohol (r = 0.24; P < 0.001), caffeine (r = 0.21; P < 0.001), and daily botanical group servings [Chenopodiaceae (r = 0.15; P < 0.05), Juglandaceae (r = 0.15; P < 0.05), Leguminosae (r = 0.20; P < 0.001), Pedaliaceae (r = 0.20; P < 0.001), and Vitaceae (r = 0.20; P < 0.001)]. Fat-related variables were not correlated with plasma enterolactone. Based on linear regression models, plasma enterolactone increased by 37.0% (SE = 2.3%) for each 10-g increase in fiber and by 6.6% (SE = 0.2%) for each 50-mg serving of caffeine. Participants consuming 0.5-1 alcoholic drink/day had plasma enterolactone concentrations that were 131.4% (SE = 37.6%) higher than those of nondrinkers. Although plasma enterolactone may be useful as a biological measure of exposure to lignan-containing foods, it may be of limited use as a specific biomarker of fruit and vegetable or plant food intake because coffee, tea, and alcoholic beverages also significantly increase its plasma concentration.
Authors:
Neilann K Horner; Alan R Kristal; JoAnn Prunty; Heather E Skor; John D Potter; Johanna W Lampe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  11     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA.
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MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / analogs & derivatives*,  blood*
Adult
Biological Markers / blood
Cross-Sectional Studies
Diet*
Female
Fruit / metabolism*
Gastrointestinal Neoplasms / prevention & control
Humans
Lignans / blood*
Male
Probability
Prospective Studies
Reference Values
Sensitivity and Specificity
Vegetables / metabolism*
Grant Support
ID/Acronym/Agency:
R01 CA 70913/CA/NCI NIH HHS; R03 CA 80648/CA/NCI NIH HHS; T32 CA 09661/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lignans; 76543-15-2/2,3-bis(3'-hydroxybenzyl)butyrolactone; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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