Document Detail

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.
MedLine Citation:
PMID:  12840166     Owner:  NLM     Status:  MEDLINE    
Anthocyanins, which are used as a food coloring, are widely distributed in human diets, suggesting that we ingest large amounts of anthocyanins from plant-based foods. Mice were fed control, cyanidin 3-glucoside-rich purple corn color (PCC), high fat (HF) or HF + PCC diet for 12 wk. Dietary PCC significantly suppressed the HF diet-induced increase in body weight gain, and white and brown adipose tissue weights. Feeding the HF diet markedly induced hypertrophy of the adipocytes in the epididymal white adipose tissue compared with the control group. In contrast, the induction did not occur in the HF + PCC group. The HF diet induced hyperglycemia, hyperinsulinemia and hyperleptinemia. These perturbations were completely normalized in rats fed HF + PCC. An increase in the tumor necrosis factor (TNF)-alpha mRNA level occurred in the HF group and was normalized by dietary PCC. These results suggest that dietary PCC may ameliorate HF diet-induced insulin resistance in mice. PCC suppressed the mRNA levels of enzymes involved in fatty acid and triacylglycerol synthesis and lowered the sterol regulatory element binding protein-1 mRNA level in white adipose tissue. These down-regulations may contribute to triacylglycerol accumulation in white adipose tissue. Our findings provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes.
Takanori Tsuda; Fumihiko Horio; Koji Uchida; Hiromitsu Aoki; Toshihiko Osawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-03     Completed Date:  2003-08-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2125-30     Citation Subset:  IM    
Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan.
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MeSH Terms
Adipose Tissue
Anthocyanins / administration & dosage*,  therapeutic use
Base Sequence
Body Weight
CCAAT-Enhancer-Binding Proteins / genetics
DNA Primers
DNA-Binding Proteins / genetics
Energy Intake
Glucosides / administration & dosage*,  therapeutic use
Hyperglycemia / drug therapy*
Insulin Resistance
Lipids / biosynthesis,  blood
Liver / enzymology,  metabolism
Mice, Inbred BALB C
Obesity / prevention & control*
Organ Size
Sterol Regulatory Element Binding Protein 1
Transcription Factors*
Reg. No./Substance:
0/Anthocyanins; 0/CCAAT-Enhancer-Binding Proteins; 0/DNA Primers; 0/DNA-Binding Proteins; 0/Glucosides; 0/Lipids; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors; 7084-24-4/cyanidin 3-O-glucoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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