| Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 20508519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) is a debilitating and widespread immune-mediated illness of unknown etiology. Current treatments are modestly successful and with significant side-effects. The purpose of this review is to summarize the current understanding of mechanisms of action underlying the anti-inflammatory actions of conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids (PUFAs) in IBD. RECENT FINDINGS: Nutrition-based interventions that target peroxisome proliferator-activated receptors (PPARs) such as dietary CLA and n-3 PUFA have demonstrated anti-inflammatory efficacy in animal models of IBD. Clinical data on n-3 PUFA in IBD remains generally unimpressive, although results of a recent human study demonstrate that IBD remission can be maintained by maintaining the n-3: n-6 ratio more than 0.65 via n-3 PUFA intervention. In mice, CLA prevented inflammation-driven colorectal cancer by activating PPAR gamma and modulating regulatory T cells and macrophages. CLA is the subject of an ongoing clinical study in Crohn's disease patients. SUMMARY: Compelling evidence demonstrates that n-3 PUFA and CLA prevent or ameliorate IBD in animal models. However, this basic knowledge has not been translated into novel nutrition-based clinical interventions. For both compounds there is an urgent need for placebo-controlled, large-scale, multicenter clinical trials. |
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Authors:
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Josep Bassaganya-Riera; Raquel Hontecillas |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 13 ISSN: 1535-3885 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2011-02-16 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 569-73 Citation Subset: IM |
Affiliation:
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Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. jbassaga@vt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colorectal Neoplasms / drug therapy, immunology Dietary Supplements* Fatty Acids, Omega-3 / pharmacology, therapeutic use* Humans Inflammatory Bowel Diseases / drug therapy*, metabolism Linoleic Acids, Conjugated / pharmacology, therapeutic use* Macrophages / drug effects, metabolism Peroxisome Proliferator-Activated Receptors / metabolism* T-Lymphocytes, Regulatory / drug effects, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AT004308-04/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Linoleic Acids, Conjugated; 0/Peroxisome Proliferator-Activated Receptors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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