| Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. | |
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MedLine Citation:
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PMID: 18258634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Choline and betaine are found in a variety of plant and animal foods and were recently shown to be associated with decreased homocysteine concentrations. OBJECTIVE: The scope of this work was to investigate the associations between dietary choline and betaine consumption and various markers of low-grade systemic inflammation. DESIGN: Under the context of a cross-sectional survey that enrolled 1514 men (18-87 y of age) and 1528 women (18-89 y of age) with no history of cardiovascular disease (the ATTICA Study), fasting blood samples were collected and inflammatory markers were measured. Dietary habits were evaluated with a validated food-frequency questionnaire, and the intakes of choline and betaine were calculated from food-composition tables. RESULTS: Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha (P < 0.01). Similarly, participants who consumed >360 mg/d of betaine had, on average, 10% lower concentrations of homocysteine (P < 0.01), 19% lower concentrations of C-reactive protein (P < 0.1), and 12% lower concentrations of tumor necrosis factor-alpha (P < 0.05) than did those who consumed <260 mg/d. These findings were independent of various sociodemographic, lifestyle, and clinical characteristics of the participants. CONCLUSIONS: Our results support an association between choline and betaine intakes and the inflammation process in free-eating and apparently healthy adults. However, further studies are needed to confirm or refute our findings. |
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Authors:
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Paraskevi Detopoulou; Demosthenes B Panagiotakos; Smaragdi Antonopoulou; Christos Pitsavos; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 87 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-08 Completed Date: 2008-03-25 Revised Date: 2008-07-31 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 424-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition Science-Dietetics, Harokopio University, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Analysis of Variance Betaine / administration & dosage* Biological Markers / blood C-Reactive Protein / metabolism* Choline / administration & dosage* Cross-Sectional Studies Diet Surveys Fasting Female Food Habits* Greece Homocysteine / blood* Humans Inflammation / blood* Interleukin-6 / blood* Life Style Lipotropic Agents / administration & dosage Male Middle Aged Tumor Necrosis Factor-alpha / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 0/Lipotropic Agents; 0/Tumor Necrosis Factor-alpha; 107-43-7/Betaine; 454-28-4/Homocysteine; 62-49-7/Choline; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2008 Jul;88(1):247-8; author reply 248
[PMID:
18614747
]
Am J Clin Nutr. 2008 Feb;87(2):277-8 [PMID: 18258614 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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