Document Detail

Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study.
MedLine Citation:
PMID:  18258634     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Choline and betaine are found in a variety of plant and animal foods and were recently shown to be associated with decreased homocysteine concentrations. OBJECTIVE: The scope of this work was to investigate the associations between dietary choline and betaine consumption and various markers of low-grade systemic inflammation. DESIGN: Under the context of a cross-sectional survey that enrolled 1514 men (18-87 y of age) and 1528 women (18-89 y of age) with no history of cardiovascular disease (the ATTICA Study), fasting blood samples were collected and inflammatory markers were measured. Dietary habits were evaluated with a validated food-frequency questionnaire, and the intakes of choline and betaine were calculated from food-composition tables. RESULTS: Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha (P < 0.01). Similarly, participants who consumed >360 mg/d of betaine had, on average, 10% lower concentrations of homocysteine (P < 0.01), 19% lower concentrations of C-reactive protein (P < 0.1), and 12% lower concentrations of tumor necrosis factor-alpha (P < 0.05) than did those who consumed <260 mg/d. These findings were independent of various sociodemographic, lifestyle, and clinical characteristics of the participants. CONCLUSIONS: Our results support an association between choline and betaine intakes and the inflammation process in free-eating and apparently healthy adults. However, further studies are needed to confirm or refute our findings.
Paraskevi Detopoulou; Demosthenes B Panagiotakos; Smaragdi Antonopoulou; Christos Pitsavos; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-03-25     Revised Date:  2008-07-31    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-30     Citation Subset:  AIM; IM    
Department of Nutrition Science-Dietetics, Harokopio University, Athens, Greece.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Betaine / administration & dosage*
Biological Markers / blood
C-Reactive Protein / metabolism*
Choline / administration & dosage*
Cross-Sectional Studies
Diet Surveys
Food Habits*
Homocysteine / blood*
Inflammation / blood*
Interleukin-6 / blood*
Life Style
Lipotropic Agents / administration & dosage
Middle Aged
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Lipotropic Agents; 0/Tumor Necrosis Factor-alpha; 107-43-7/Betaine; 454-28-4/Homocysteine; 62-49-7/Choline; 9007-41-4/C-Reactive Protein
Comment In:
Am J Clin Nutr. 2008 Jul;88(1):247-8; author reply 248   [PMID:  18614747 ]
Am J Clin Nutr. 2008 Feb;87(2):277-8   [PMID:  18258614 ]

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