| Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons. | |
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MedLine Citation:
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PMID: 20639007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous work has shown high dietary cholesterol can affect learning and memory including rabbit eyeblink conditioning and this effect may be due to increased membrane cholesterol and enhanced hippocampal amyloid beta production. This study investigated whether dietary cholesterol modulates rabbit hippocampal CA1 neuron membrane properties known to be involved in rabbit eyeblink conditioning. Whole-cell current clamp recordings in hippocampal neurons from rabbits fed 2 percent cholesterol or normal chow for 8 weeks revealed changes including decreased after-hyperpolarization amplitudes (AHPs) - an index of membrane excitability shown to be important for rabbit eyeblink conditioning. This index was reversed by adding copper to drinking water - a dietary manipulation that can retard rabbit eyeblink conditioning. Evidence of cholesterol effects on membrane excitability was provided by application of methyl-beta-cyclodextrin, a compound that reduces membrane cholesterol, which increased the excitability of hippocampal CA1 neurons. |
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Authors:
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Desheng Wang; Bernard G Schreurs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neuroscience letters Volume: 479 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-09-27 Revised Date: 2011-08-04 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 327-31 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States. dwang@hsc.wvu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CA1 Region, Hippocampal / drug effects*, physiology Cell Membrane / drug effects, physiology Cholesterol, Dietary / pharmacology* Copper Sulfate / pharmacology Male Patch-Clamp Techniques Pyramidal Cells / drug effects*, physiology Rabbits beta-Cyclodextrins / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AG023211/AG/NIA NIH HHS; R01 AG023211-05A1/AG/NIA NIH HHS; R01 AG023211-07/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/beta-Cyclodextrins; 0/methyl-beta-cyclodextrin; 7758-98-7/Copper Sulfate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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