Document Detail

Dietary cholesterol, fatty acids, and the risk of lung cancer among men.
MedLine Citation:
PMID:  1775388     Owner:  NLM     Status:  MEDLINE    
The relation between dietary cholesterol and fatty acids and the incidence of lung cancer was studied among 4,538 Finnish men aged 20-69 years and initially free of cancer. During 20 years of follow-up, 117 lung cancer cases were diagnosed. Cholesterol intake was not associated with lung cancer risk, the age-, smoking-, and energy-adjusted relative risk between the lowest and highest tertiles being 1.0 [95% confidence interval (CI) = 0.6-1.9]. The intake of saturated fatty acids was nonsignificantly related with lung cancer incidence, the relative risk for the lowest compared with the highest tertile being 1.6 (CI = 0.8-3.2). The association was stronger among smokers than among nonsmokers, the relative risks being 2.1 (CI = 1.0-4.3) and 1.3 (CI = 0.4-4.1), respectively. The relative risk among smokers, however, decreased to 1.5 after adjustment for the amount they smoked. In the total cohort, there was a significantly elevated risk of lung cancer among men with a high intake of butter, one of the main sources of saturated fatty acids, the relative risk being 1.9 (CI = 1.1-3.2). The present data do not confirm previous results suggesting that dietary cholesterol predicts the occurrence of lung cancer among men. The association between intake of saturated fatty acids and lung cancer observed in the present study may be partly due to heavy smoking among high consumers of saturated fat.
P Knekt; R Seppänen; R Järvinen; J Virtamo; L Hyvönen; E Pukkala; L Teppo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  16     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Research Institute for Social Security, Social Insurance Institution, Helsinki, Finland.
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MeSH Terms
Age Factors
Cholesterol, Dietary / adverse effects*
Dietary Fats / adverse effects*
Energy Intake
Fatty Acids / adverse effects*
Lung Neoplasms / etiology*
Middle Aged
Smoking / adverse effects
Grant Support
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Dietary Fats; 0/Fatty Acids

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