Document Detail


Dietary cholesterol alters memory and synaptic structural plasticity in young rat brain.
MedLine Citation:
PMID:  23187788     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cholesterol plays an important role in synaptic plasticity, learning and memory. To better explore how dietary cholesterol contributes to learning and memory and the related changes in synaptic structural plasticity, rats were categorized into a regular diet (RD) group and a cholesterol-enriched diet (CD) group, and were fed with respective diet for 2 months. Dietary cholesterol impacts on learning and memory, hippocampal synaptic ultrastructure, expression levels of postsynaptic density-95 (PSD-95), synaptophysin (SYP) and cannabinoid receptor type 1 (CB1R) were investigated. We found CD rats had better performances in learning and memory using Morris water maze and object recognition test than RD rats. The memory improvement was accompanied with alterations of synaptic ultrastructure in the CA1 area of the hippocampus evaluated by electron microscopy, enhanced immunoreactivity of SYP, a presynaptic marker in hippocampus detected by immunocytochemistry, as well as increased levels of PSD-95, SYP and decreased level of CB1R in brains of CD rats determined by Western blot. Taken together, the results suggest that the improvement of learning and memory abilities of the young adult rats induced by dietary cholesterol may be linked with changes in synaptic structural plasticity in the brain.
Authors:
Bai-Liu Ya; Wen-Yan Liu; Feng Ge; Yan-Xia Zhang; Bao-Liang Zhu; Bo Bai
Related Documents :
23751508 - Association among energy status, subclinical endometritis postpartum and subsequent rep...
20655438 - Comparison of fermentation of diets of variable composition and microbial populations i...
22980388 - The isoflavone-rich fraction of the crude extract of the puerariae flower increases oxy...
23589408 - Amelioration of hepatotoxicity induced by aflatoxin using citrus fruit oil in broilers ...
2713878 - Dietary fat influences electric membrane properties of neurons in cell culture.
2823908 - Comparative effects of dietary fish oil and carbohydrate on plasma lipids and hepatic a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  -     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Physiology, Jining Medical University, Shandong, 272067, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Azadirachta indica mitigates behavioral impairments, oxidative damage, histological alterations and ...
Next Document:  Influence of chronic caffeine on MDMA-induced behavioral and neuroinflammatory response in mice.