Document Detail

Dietary carotenoids and risk of breast cancer in Chinese women.
MedLine Citation:
PMID:  17392146     Owner:  NLM     Status:  MEDLINE    
There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, the protective effect of carotenoids on breast cancer has been inconclusive. To investigate whether intake of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin is inversely associated with breast cancer risk, a case-control study was conducted in China during 2004-2005. The cases were 122 female patients aged 24-87 years with histopathologically confirmed breast cancer. 632 healthy women age-matched were randomly recruited from outpatient clinics. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable food frequency questionnaire. The USDA nutrient composition database was used to calculate intake of the specific carotenoids. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), accounting for age, locality, education, body mass index, smoking, passive smoking, physical activity, number of children breastfed, menopausal status, oral contraceptive use, biopsy-confirmed benign breast diseases, family history of breast cancer, and total energy intake. Compared with the highest versus lowest quartile of intake, the adjusted ORs were 0.26 (95% CI 0.14-0.46) for lycopene, 0.38 (95% CI 0.21-0.71) for beta-carotene, 0.43 (95% CI 0.23-0.82) for beta-cryptoxanthin, and 0.37 (95% CI 0.20-0.68) for total carotenoids, with statistically significant tests for trend. There was no association with breast cancer for alpha-carotene and lutein/zeaxanthin. It is concluded that higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women. More research to examine the relationship between carotenoids and breast cancer risk is warranted.
Jiang-ping Huang; Min Zhang; C D'Arcy J Holman; Xing Xie
Related Documents :
1399136 - A population-based case-control study of cancers of the nasal cavity and paranasal sinu...
9103316 - Health beliefs and health behaviours in subpopulation of stomach cancer families and in...
25474046 - Comparison of conventional culture method and fluorescent in situ hybridization techniq...
3615216 - Vitamin a and other dietary factors in the etiology of esophageal cancer.
15214816 - Massive thyroid tumoral embolism from a breast carcinoma presenting as acute thyroiditis.
23279696 - Alkbh2, a novel alkb homologue, contributes to human bladder cancer progression by regu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  16 Suppl 1     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Women's Hospital, School of Medicine, Zhejiang University, P.R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Anticarcinogenic Agents / administration & dosage*
Breast Neoplasms / epidemiology*
Carotenoids / administration & dosage*
Case-Control Studies
China / epidemiology
Confidence Intervals
Diet Surveys*
Life Style*
Logistic Models
Middle Aged
Odds Ratio
Risk Factors
Xanthophylls / administration & dosage
beta Carotene / administration & dosage
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Xanthophylls; 36-88-4/Carotenoids; 472-70-8/cryptoxanthin; 502-65-8/lycopene; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antiproliferative effects of conjugated linoleic acid on human colon adenocarcinoma cell line Caco-2...
Next Document:  Inhibitory effects of vegetable and fruit ferment liquid on tumor growth in Hepatoma-22 inoculation ...