Document Detail


Dietary carotenoids and risk of breast cancer in Chinese women.
MedLine Citation:
PMID:  17392146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, the protective effect of carotenoids on breast cancer has been inconclusive. To investigate whether intake of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin is inversely associated with breast cancer risk, a case-control study was conducted in China during 2004-2005. The cases were 122 female patients aged 24-87 years with histopathologically confirmed breast cancer. 632 healthy women age-matched were randomly recruited from outpatient clinics. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable food frequency questionnaire. The USDA nutrient composition database was used to calculate intake of the specific carotenoids. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), accounting for age, locality, education, body mass index, smoking, passive smoking, physical activity, number of children breastfed, menopausal status, oral contraceptive use, biopsy-confirmed benign breast diseases, family history of breast cancer, and total energy intake. Compared with the highest versus lowest quartile of intake, the adjusted ORs were 0.26 (95% CI 0.14-0.46) for lycopene, 0.38 (95% CI 0.21-0.71) for beta-carotene, 0.43 (95% CI 0.23-0.82) for beta-cryptoxanthin, and 0.37 (95% CI 0.20-0.68) for total carotenoids, with statistically significant tests for trend. There was no association with breast cancer for alpha-carotene and lutein/zeaxanthin. It is concluded that higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women. More research to examine the relationship between carotenoids and breast cancer risk is warranted.
Authors:
Jiang-ping Huang; Min Zhang; C D'Arcy J Holman; Xing Xie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  16 Suppl 1     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Affiliation:
Women's Hospital, School of Medicine, Zhejiang University, P.R. China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anticarcinogenic Agents / administration & dosage*
Breast Neoplasms / epidemiology*
Carotenoids / administration & dosage*
Case-Control Studies
China / epidemiology
Confidence Intervals
Diet Surveys*
Female
Humans
Life Style*
Logistic Models
Middle Aged
Odds Ratio
Questionnaires
Risk Factors
Xanthophylls / administration & dosage
beta Carotene / administration & dosage
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Xanthophylls; 36-88-4/Carotenoids; 472-70-8/cryptoxanthin; 502-65-8/lycopene; 7235-40-7/beta Carotene

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