Document Detail

Dietary canola and soybean oil fed to SHRSP rat dams differently affect the growth and survival of their male pups.
MedLine Citation:
PMID:  15173395     Owner:  NLM     Status:  MEDLINE    
Canola oil (Can), as well as some other oils, shortens the survival of SHRSP rats compared with soybean oil (Soy). Although detrimental factors other than phytosterols have not been identified, they are likely to be hydrophobic and transmissible to pups. To test this possibility, female SHRSP rats (F0) were fed a diet supplemented with Can or Soy and mated at 11 wk of age. The growth of suckling pups (F1) from the Can-fed dams was significantly retarded compared with that of pups from the Soy-fed dams. Half of the male pups (F1) were weaned to the same diet as their dams (Can-->Can and Soy-->Soy groups) and the rest were weaned to the other diet (Can-->Soy and Soy-->Can groups). The survival rate of the male pups (F1) was significantly lower in the Can-->Can group than in the Soy-->Can group, and in the Can-->Soy group than in the Soy-->Soy group, indicating that the oils fed to dams differently affected the growth and survival of pups. There were fewer pups per dam in the Can-fed dams (F0) than in the Soy-fed dams, and in the dams (F1) of the Can-->Can and Soy-->Can groups than in those of the Can-->Soy and Soy-->Soy groups. Although Can is nutritionally detrimental to SHRSP rats compared with Soy, no direct evidence has been obtained thus far relating these observations to human nutrition.
Kenjiro Tatematsu; Shin-ya Fuma; Junichi Satoh; Yuko Ichikawa; Yoichi Fujii; Harumi Okuyama
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2004-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1347-52     Citation Subset:  IM    
Department of Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
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MeSH Terms
Dietary Fats, Unsaturated / adverse effects,  pharmacology*
Fatty Acids / analysis,  blood
Fatty Acids, Monounsaturated / adverse effects,  pharmacology*
Genetic Predisposition to Disease
Growth / drug effects
Lipids / analysis
Milk / chemistry
Pregnancy, Animal* / blood,  metabolism
Prenatal Exposure Delayed Effects*
Rats, Inbred SHR / genetics
Sex Characteristics
Soybean Oil / adverse effects,  pharmacology*
Sterols / analysis,  blood
Stroke / genetics*
Survival Analysis
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Lipids; 0/Sterols; 120962-03-0/canola oil; 8001-22-7/Soybean Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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