Document Detail


Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial.
MedLine Citation:
PMID:  12606887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pregnancy and breastfeeding mobilize lead stored in bone, which may be a hazard for the fetus and infant. We tested the hypothesis that in lactating women a dietary calcium supplement will lower blood lead levels. METHODS: Between 1994 and 1995 we conducted a randomized trial among women in Mexico City. Lactating women (N = 617; mean age = 24 years; mean blood lead level = 8.5 ug/dL) were randomly assigned to receive either calcium carbonate (1200 mg of elemental calcium daily) or placebo in a double-blind trial. Blood samples were obtained at baseline, and 3 and 6 months after the trial began. Blood lead was determined by graphite furnace atomic absorption spectroscopy. Bone lead was measured at baseline with a 109cd K x-ray fluorescence instrument. The primary endpoint was change in maternal blood lead level, which was analyzed in relation to supplement use and other covariates by multivariate generalized linear models for longitudinal observations. RESULTS: An intention-to-treat analysis showed that women randomized to the calcium supplements experienced a small decline in blood lead levels (overall reduction of 0.29 ug/dL; 95% confidence interval = -0.85 to 0.26). The effect was more apparent among women who were compliant with supplement use and had high bone lead levels (patella bone lead > or =5 microg/gm bone). Among this subgroup, supplement use was associated with an estimated reduction in mean blood lead of 1.16 ug/dL (95% confidence interval = -2.08 to -0.23), an overall reduction of 16.4%. CONCLUSIONS: Among lactating women with relatively high lead burden, calcium supplementation was associated with a modest reduction in blood lead levels.
Authors:
Mauricio Hernandez-Avila; Teresa Gonzalez-Cossio; Juan E Hernandez-Avila; Isabelle Romieu; Karen E Peterson; Antonio Aro; Eduardo Palazuelos; Howard Hu
Related Documents :
9641707 - Accuracy and reproducibility of blood lead testing in commercial laboratories.
3767287 - Delta-aminolaevulinic acid dehydratase as an index of the presence and severity of lead...
20199067 - Feather lead concentrations and (207)pb/(206)pb ratios reveal lead exposure history of ...
17383727 - Sublethal toxicity of the prestige oil spill on yellow-legged gulls.
20645267 - [the blood-brain barrier and drug delivery in the central nervous system].
3308557 - The blood vessel wall as an insulin target tissue.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  14     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-27     Completed Date:  2003-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  IM    
Affiliation:
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico. mhernan@correo.insp.mx
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bone and Bones / chemistry,  metabolism
Calcium Carbonate / administration & dosage*
Double-Blind Method
Female
Humans
Lactation / metabolism*
Lead / blood*,  pharmacokinetics
Linear Models
Placebos
Questionnaires
Spectrophotometry, Atomic
Grant Support
ID/Acronym/Agency:
2 P30 ES00002/ES/NIEHS NIH HHS; P42-ES05947/ES/NIEHS NIH HHS; R01ES07821/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Placebos; 471-34-1/Calcium Carbonate; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Folate intake and the risk of neural tube defects: an estimation of dose-response.
Next Document:  Validation of a food frequency questionnaire in preschool children.