Document Detail

Dietary calcium supplementation restores pressure natriuresis responses in Dahl-S rats.
MedLine Citation:
PMID:  7662246     Owner:  NLM     Status:  MEDLINE    
Calcium supplementation prevents hypertension in Dahl S (DS) rats. Because abnormal pressure natriuresis may contribute to the development of hypertension, we examined the effect of calcium on pressure natriuresis. DS and Dahl R (DR) rats maintained on a 4% sodium diet containing either 0.5% or 2% calcium for 4 weeks were anesthetized; sodium excretion, renal blood flow, and inulin clearance were determined at perfusion pressures of 100, 125, and 156 mm Hg. Inulin clearance and renal blood flow were not different between groups. Sodium excretion increased with increasing renal perfusion pressure in all groups. The slope of the line relating renal perfusion pressure to sodium excretion was greater (P < .05) in DR rats than in DS rats on normal calcium intakes. High calcium intake normalized the slope of the line relating renal perfusion pressure to sodium excretion in DS rats, but had no effect on DR rats. Thus, dietary calcium supplementation normalizes the blunted pressure natriuresis response in the DS rat and may contribute to the prevention of hypertension.
T V Butler; J Cameron; K A Kirchner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  8     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-11     Completed Date:  1995-10-11     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
Jackson State University, Mississippi, USA.
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MeSH Terms
Blood Pressure / drug effects*
Calcium / urine
Calcium, Dietary / pharmacology*
Kidney / drug effects
Natriuresis / drug effects*
Organ Size / drug effects
Rats, Inbred Strains
Regional Blood Flow / drug effects
Renal Circulation / drug effects
Sodium, Dietary / adverse effects
Urodynamics / drug effects
Reg. No./Substance:
0/Calcium, Dietary; 0/Sodium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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