Document Detail

Dietary calcium supplementation, blood pressure, and intestinal calcium absorption.
MedLine Citation:
PMID:  8141149     Owner:  NLM     Status:  MEDLINE    
This study investigated the potential intestinal mechanism in the blood pressure-lowering effect of dietary calcium supplement. Adult Wistar rats received, through a gastrotomy cannula, either 5 or 30 mg elemental calcium.d-1 x 100 g BW-1 for 10 days. At day 11, mean arterial pressure was measured directly in anesthetized animals and calcium absorption determined using an in situ measurement technique of calcium absorption. An intestinal loop (duodenum and proximal jejunum) was perfused both by the intraluminal and the vascular routes. A solution containing 45Ca was perfused intraluminally and the 45Ca appearing in the venous effluent was determined to estimate calcium absorption. Oral calcium supplementation caused intestinal calcium uptake by the isolated loop to increase almost twofold. It also resulted in an 18% increase in mesenteric blood flow. The mean arterial pressure was decreased in calcium supplemented rats compared with control rats (87 +/- 5 vs. 78 +/- 5 mmHg; p < 0.05). These findings could indicate that the passive part of intestinal calcium transport increases in response to dietary calcium supplement. This improvement may participate in the blood pressure-lowering effect of a high calcium diet.
R Schleiffer; M Galluser; J Kachelhoffer; F Raul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  307 Suppl 1     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-28     Completed Date:  1994-04-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S116-9     Citation Subset:  AIM; IM    
Unité de Biologie Cellulaire et Physiologie Digestives, INSERM U61, Strasbourg, France.
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MeSH Terms
Blood Pressure / drug effects*
Calcium / metabolism*
Calcium, Dietary / administration & dosage*
Intestinal Absorption*
Rats, Wistar
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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