| Dietary calcium consumption and astrocytic glioma: the San Francisco Bay Area Adult Glioma Study, 1991-1995. | |
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MedLine Citation:
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PMID: 11759280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies suggest an association between calcium consumption and glioma risk. In the present study, we compare consumption of calcium and other dairy components and foods (cholesterol, fat, protein, calories, milk, and cheese) of 337 astrocytic glioma case patients with 450 controls from the San Francisco Bay Area Adult Glioma Study, 1991-1995. We use unconditional logistic regression models to estimate odds ratios (ORs) by gender controlling for age, education, and income. A statistically significant inverse association [p (trend) = 0.05] was observed for dietary calcium intake for women only [OR = 0.49, 95% confidence interval (CI) = 0.24-1.03 for highest vs. lowest quartile of consumption]. In addition, we observed elevated ORs for highest vs. lowest quartiles of cholesterol intake among women and men (OR = 2.07, 95% CI = 1.00-4.28 and OR = 1.75, 95% CI = 0.92-3.31, respectively). Calcium may exert a protective effect through its known roles in apoptosis, DNA repair, and inhibition of parathyroid hormone production. Recent evidence suggests that parathyroid hormone may influence growth and dedifferentiation of astrocytoma cells. Finally, circulating estradiol might directly stimulate intestinal absorption of calcium and may therefore explain why the inverse association of calcium intake and glioma is confined to women. |
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Authors:
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N Tedeschi-Blok; J Schwartzbaum; M Lee; R Miike; M Wrensch; |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nutrition and cancer Volume: 39 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 2001 |
Date Detail:
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Created Date: 2001-12-10 Completed Date: 2002-04-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 196-203 Citation Subset: IM |
Affiliation:
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Division of Epidemiology and Biometrics, School of Public Health, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Astrocytoma / epidemiology*, prevention & control Calcium, Dietary / administration & dosage* Case-Control Studies Cheese Cholesterol, Dietary / administration & dosage Diet Dietary Fats / administration & dosage Dietary Proteins / administration & dosage Educational Status Energy Intake Female Humans Income Logistic Models Male Middle Aged Milk Odds Ratio San Francisco / epidemiology Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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R01CA-52689/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary; 0/Cholesterol, Dietary; 0/Dietary Fats; 0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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