Document Detail

Dietary calcium and blood pressure: modifying factors in specific populations.
MedLine Citation:
PMID:  2053565     Owner:  NLM     Status:  MEDLINE    
Epidemiologic findings continue to add to the body of evidence supporting a relationship between calcium intake and blood pressure. These findings also indicate that there is a threshold of the potential protective effect of adequate calcium intake, below which the risk of hypertension increases at a greater rate. The set point of this threshold, estimated at 700-800 mg/d, may be modified by a variety of factors including dietary patterns and components, lifestyle, and genetics. This may explain, at least in part, the heterogeneous response observed in dietary-intervention studies. In animal models of hypertension it was shown that greater amounts of calcium must be given to cause a blood pressure change comparable with that in normal animals, suggesting that in high-risk human populations in which calcium metabolism may be disordered, calcium intake may have to be increased to amounts greater than 700-800 mg/d to demonstrate the blood-pressure-lowering effect. Calcium intake at or above the currently recommended daily allowance of 800 mg could be of potential benefit to certain racial groups, individuals ingesting excessive alcohol, and pregnant women, all of whom generally consume low amounts of calcium and who are at higher risk of developing hypertension.
D A McCarron; C D Morris; E Young; C Roullet; T Drüeke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  54     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215S-219S     Citation Subset:  AIM; IM    
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Blood Pressure / drug effects*
Calcium, Dietary / pharmacology*,  therapeutic use
Databases, Bibliographic
Disease Models, Animal
Hypertension / prevention & control*
Rats, Inbred SHR
Reg. No./Substance:
0/Calcium, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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