Document Detail


Dietary and blood antioxidants in patients with chronic heart failure. Insights into the potential importance of selenium in heart failure.
MedLine Citation:
PMID:  11738217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic heart failure (CHF) seems to be associated with increased oxidative stress. However, the hypothesis that antioxidant nutrients may contribute to the clinical severity of the disease has never been investigated.
AIMS: To examine whether antioxidant nutrients influence the exercise capacity and left ventricular function in patients with CHF.
METHODS: Dietary intake and blood levels of major antioxidant nutrients were evaluated in 21 consecutive CHF patients and in healthy age- and sex-matched controls. Two indexes of the severity of CHF, peak exercise oxygen consumption (peak VO2) and left ventricular ejection fraction (LVEF), were measured and their relations with antioxidants were analysed.
RESULTS: Whereas plasma alpha-tocopherol and retinol were in the normal range, vitamin C (P=0.005) and beta-carotene (P=0.01) were lower in CHF. However, there was no significant association between vitamins and either peak VO2 or LVEF. Dietary intake (P<0.05) and blood levels of selenium (P<0.0005) were lower in CHF. Peak VO2 (but not LVEF) was strongly correlated with blood selenium: r=0.76 by univariate analysis (polynomial regression) and r=0.87 (P<0.0005) after adjustment for age, sex and LVEF.
CONCLUSIONS: Antioxidant defences are altered in patients with CHF. Selenium may play a role in the clinical severity of the disease, rather than in the degree of left ventricular dysfunction. Further studies are warranted to confirm the data in a large sample size and to investigate the mechanisms by which selenium and other antioxidant nutrients are involved in CHF.
Authors:
M de Lorgeril; P Salen; M Accominotti; M Cadau; J P Steghens; F Boucher; J de Leiris
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  3     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-16     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  661-9     Citation Subset:  IM    
Affiliation:
Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Médecine et Pharmacie, Université Joseph Fourier de Grenoble, Domaine de la Merci, 38706 La Tronche, Grenoble, France. michel.delorgeril@ujf-grenoble.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antioxidants / metabolism*,  therapeutic use*
Ascorbic Acid / metabolism,  therapeutic use
Cardiomyopathies / blood,  complications,  diet therapy
Chronic Disease
Female
Food Habits / physiology*
Heart Failure / blood*,  complications,  psychology*
Humans
Male
Middle Aged
Oxidative Stress / physiology
Selenium / metabolism*,  therapeutic use*
Ventricular Function, Left / drug effects
beta Carotene / metabolism,  therapeutic use
Chemical
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene; 7782-49-2/Selenium

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