Document Detail

Dietary ascorbic acid and muscle carnitine (beta-OH-gamma-(trimethylamino) butyric acid) in guinea-pigs.
MedLine Citation:
PMID:  7378344     Owner:  NLM     Status:  MEDLINE    
Tissue ascorbic acid (AA) contents of approximately 12 and 100% saturation respectively were produced in two groups of guinea-pigs. The 'low-AA' group had a significantly lower muscle carnitine concentrations than the 'high-AA' group. There was no concomitant emergence of the symptoms customarily regarded as characteristic of hypovitaminosis C. It is concluded that muscle carnitine (beta-OH-gamma-(trimethyl-amino)butyric acid) is a highly-sensitive indicator of tissue AA contents; this could account for the lassitude and fatique reported to precede the emergence of frank scurvy in man.
R E Hughes; R J Hurley; E Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  43     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  385-7     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / analysis
Ascorbic Acid Deficiency / metabolism*
Carnitine / analysis*
Guinea Pigs
Muscles / analysis*
Reg. No./Substance:
50-81-7/Ascorbic Acid; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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