Document Detail

Dietary antioxidants and the risk of ischemic stroke: the Rotterdam Study.
MedLine Citation:
PMID:  14610137     Owner:  NLM     Status:  MEDLINE    
In the Rotterdam Study, the authors investigated whether high intake of antioxidants from food is associated with the risk of stroke. Among 5,197 participants who were followed on average for 6.4 years, 227 ischemic strokes occurred. Higher intake of antioxidants was associated with a lower risk of stroke. The relationship was dose-dependent, significant for vitamin C, and most pronounced in smokers. These results agree with the view that high dietary intake of antioxidants, in particular vitamin C and--in smokers--vitamin E, reduces the risk of stroke.
Z Vokó; M Hollander; A Hofman; P J Koudstaal; M M B Breteler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  61     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1273-5     Citation Subset:  AIM; IM    
Department of Epidemiology & Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands.
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MeSH Terms
Antioxidants / administration & dosage*
Ascorbic Acid / administration & dosage
Brain Ischemia / epidemiology*,  prevention & control*
Cohort Studies
Follow-Up Studies
Netherlands / epidemiology
Risk Reduction Behavior
Stroke / epidemiology*,  prevention & control*
Vitamin E / administration & dosage
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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