Document Detail


Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an australian population.
MedLine Citation:
PMID:  23292980     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of non-dysplastic BE, dysplastic BE and EAC associated with intake of antioxidants such as vitamin C, vitamin E, β-carotene, and selenium. Age and sex matched control subjects (n = 577 for BE; n=1507 for EAC) were sampled from an Australian population register. Information on demography, and well established EAC risk factors were obtained using self-administered questionnaires. Intake of antioxidants for patients newly diagnosed with non-dysplastic BE (n = 266), dysplastic BE (n=101), or EAC (n = 299), aged 18 to 79 years, were obtained using a food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable adjusted logistic regression models. High intake of β-carotene from food and supplement sources combined was inversely associated with risk of dysplastic BE (OR Q4 vs Q1=0.45; 95%CI: 0.20-1.00). High intake of vitamin E from food sources (OR Q4 vs Q1=0.43; 95%CI: 0.28-0.67), from food and supplements combined (OR Q4 vs Q1=0.64; 95%CI: 0.43-0.96), and a high antioxidant index score were inversely associated with risk of EAC. We found no significant trends between intake of β-carotene, vitamin C, vitamin E, and selenium and risk of non-dysplastic or dysplastic BE. However, our data suggest that a high intake of β-carotene may be associated with decreased risk of dysplastic BE. (Word count=249). © 2013 Wiley Periodicals, Inc.
Authors:
Torukiri I Ibiebele; Maria Celia Hughes; Christina M Nagle; Christopher J Bain; David C Whiteman; Penelope M Webb
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Affiliation:
Population Health Department, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia. Torukiri.Ibiebele@qimr.edu.au.
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