Document Detail


Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma.
MedLine Citation:
PMID:  11480500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ozone exposure aggravates asthma, as has been demonstrated in both controlled exposures and epidemiologic studies. In the current double-blind crossover study, the authors evaluated the effects of dietary antioxidants (i.e., 400 IU vitamin E/500 mg vitamin C) on ozone-induced bronchial hyperresponsiveness in adult subjects with asthma. Seventeen subjects were exposed to 0.12 ppm of ozone or to air for 45 min during intermittent moderate exercise. Bronchial hyperresponsiveness was assessed with 10-min sulfur dioxide (i.e., 0.10 ppm and 0.25 ppm) inhalation challenges. Subjects who were given dietary antioxidants responded less severely to sulfur dioxide challenge than subjects given a placebo (i.e., forced expiratory volume in the 1st sec: -1.2% vs. 4.4%, respectively; peak flow: +2.2% vs. -3.0%, respectively; and mid-forced expiratory flow: +2.0% vs. -4.3%, respectively). Effects were more pronounced when subjects were grouped by response to sulfur dioxide at the screening visit. The results suggest that dietary supplementation with vitamins E and C benefits asthmatic adults who are exposed to air pollutants.
Authors:
C A Trenga; J Q Koenig; P V Williams
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of environmental health     Volume:  56     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-08-01     Completed Date:  2001-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  242-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Environmental Health, University of Washington, Seattle 98195-7234, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollutants / adverse effects*
Airway Resistance / drug effects
Antioxidants / pharmacology*,  therapeutic use*
Ascorbic Acid / pharmacology,  therapeutic use
Asthma / chemically induced,  prevention & control*
Cross-Over Studies
Dietary Supplements*
Double-Blind Method
Exercise Test
Female
Humans
Male
Ozone / adverse effects*
Sulfur Dioxide / diagnostic use
Vitamin E / pharmacology,  therapeutic use
Grant Support
ID/Acronym/Agency:
DK35816/DK/NIDDK NIH HHS; P30 ES07033/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Antioxidants; 10028-15-6/Ozone; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7446-09-5/Sulfur Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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