Document Detail

Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles.
MedLine Citation:
PMID:  16806493     Owner:  NLM     Status:  MEDLINE    
The study objective was to determine the effects of feeding food enriched in antioxidants and a program of environmental/cognitive enrichment on selected ex vivo assays of inflammatory and immune cells in healthy geriatric Beagle dogs (n=21). Four groups of dogs were tested using a 2 x 2 factorial design. The 2-year longitudinal study included both nutritional (control food or antioxidant-fortified food) and behavioral (normal level or cognitive enrichment) interventions. Behavior enrichment included increased exercise, environmental enrichment, and a series of learning tasks. Phagocytosis of opsonized latex-coated beads by peripheral blood neutrophils was measured by flow cytometry and found to be significantly increased in dogs receiving both dietary antioxidants and cognitive enrichment. Simultaneous stimulation of cells with Con A and suppression with Dex resulted in decreased lymphocyte proliferation in dogs receiving both dietary antioxidants and cognitive enrichment, compared to dogs receiving dietary antioxidants or cognitive enrichment alone. There were no significant differences between the groups of dogs for percentages of CD4 and CD8 T-lymphocyte subpopulations before or after lymphocyte stimulation with Con A. These results support our hypothesis that both dietary antioxidants and behavioral enrichment enhance host defense mechanisms.
Jean A Hall; Rebecca A Picton; Phyllis S Finneran; Karyn E Bird; Monica M Skinner; Dennis E Jewell; Steven Zicker
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Publication Detail:
Type:  Journal Article     Date:  2006-06-27
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  113     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-10-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  224-33     Citation Subset:  IM    
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
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MeSH Terms
Aging / immunology
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Behavior, Animal / physiology
CD4-Positive T-Lymphocytes / cytology,  immunology
CD8-Positive T-Lymphocytes / cytology,  immunology
Carnitine / pharmacology
Dogs / immunology*
Flow Cytometry / veterinary
Immunophenotyping / veterinary
Leukotriene B4 / analysis,  immunology
Longitudinal Studies
Neutrophil Activation / drug effects,  immunology
Neutrophils / immunology*
Phagocytosis / drug effects,  immunology
Physical Conditioning, Animal
Thioctic Acid / pharmacology
Tumor Necrosis Factor-alpha / analysis,  immunology
alpha-Tocopherol / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Tumor Necrosis Factor-alpha; 1406-66-2/Tocopherols; 50-81-7/Ascorbic Acid; 541-15-1/Carnitine; 59-02-9/alpha-Tocopherol; 62-46-4/Thioctic Acid; 71160-24-2/Leukotriene B4

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