| Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles. | |
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MedLine Citation:
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PMID: 16806493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study objective was to determine the effects of feeding food enriched in antioxidants and a program of environmental/cognitive enrichment on selected ex vivo assays of inflammatory and immune cells in healthy geriatric Beagle dogs (n=21). Four groups of dogs were tested using a 2 x 2 factorial design. The 2-year longitudinal study included both nutritional (control food or antioxidant-fortified food) and behavioral (normal level or cognitive enrichment) interventions. Behavior enrichment included increased exercise, environmental enrichment, and a series of learning tasks. Phagocytosis of opsonized latex-coated beads by peripheral blood neutrophils was measured by flow cytometry and found to be significantly increased in dogs receiving both dietary antioxidants and cognitive enrichment. Simultaneous stimulation of cells with Con A and suppression with Dex resulted in decreased lymphocyte proliferation in dogs receiving both dietary antioxidants and cognitive enrichment, compared to dogs receiving dietary antioxidants or cognitive enrichment alone. There were no significant differences between the groups of dogs for percentages of CD4 and CD8 T-lymphocyte subpopulations before or after lymphocyte stimulation with Con A. These results support our hypothesis that both dietary antioxidants and behavioral enrichment enhance host defense mechanisms. |
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Authors:
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Jean A Hall; Rebecca A Picton; Phyllis S Finneran; Karyn E Bird; Monica M Skinner; Dennis E Jewell; Steven Zicker |
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Publication Detail:
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Type: Journal Article Date: 2006-06-27 |
Journal Detail:
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Title: Veterinary immunology and immunopathology Volume: 113 ISSN: 0165-2427 ISO Abbreviation: Vet. Immunol. Immunopathol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2006-10-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8002006 Medline TA: Vet Immunol Immunopathol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 224-33 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA. Jean.Hall@oregonstate.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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immunology Animals Antioxidants / pharmacology* Ascorbic Acid / pharmacology Behavior, Animal / physiology CD4-Positive T-Lymphocytes / cytology, immunology CD8-Positive T-Lymphocytes / cytology, immunology Carnitine / pharmacology Dogs / immunology* Female Flow Cytometry / veterinary Immunophenotyping / veterinary Leukotriene B4 / analysis, immunology Longitudinal Studies Male Neutrophil Activation / drug effects, immunology Neutrophils / immunology* Phagocytosis / drug effects, immunology Physical Conditioning, Animal Thioctic Acid / pharmacology Tocopherols Tumor Necrosis Factor-alpha / analysis, immunology alpha-Tocopherol / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Tumor Necrosis Factor-alpha; 1406-66-2/Tocopherols; 50-81-7/Ascorbic Acid; 541-15-1/Carnitine; 59-02-9/alpha-Tocopherol; 62-46-4/Thioctic Acid; 71160-24-2/Leukotriene B4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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