Document Detail

Dietary antioxidants as potential pharmacological agents for ischemic stroke.
MedLine Citation:
PMID:  18473816     Owner:  NLM     Status:  MEDLINE    
Acute ischemic stroke is a leading cause of death and severe disability in industrialised countries and also in many developing countries. An excessive amount of free radicals is generated during cerebral ischemia, which significantly contributes to brain damage. Therefore, an increasing interest has been devoted to the potential benefits of antioxidant compounds in ischemic stroke patients. In this review, we examined the most relevant observational studies concerning the relationship between dietary antioxidants and ischemic stroke as well as clinical trials investigating the effects of single or multiple antioxidant supplementation in the prevention or treatment of acute ischemic stroke. Furthermore, we reviewed the most promising antioxidant compounds, i.e. dehydroascorbic acid, alpha-tocotrienol, gamma-tocopherol, flavonoids, resveratrol and gingko biloba, tested in animal models of acute ischemic stroke. Finally, we carefully evaluated the reasons for the discrepancy between experimental and clinical studies, and provided recommendations to improve the translation of the results obtained in animal models to patients with acute ischemic stroke.
A Cherubini; C Ruggiero; C Morand; F Lattanzio; G Dell'aquila; G Zuliani; A Di Iorio; C Andres-Lacueva
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  15     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1236-48     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Institute of Gerontology and Geriatrics, Policlinico Monteluce, Pad. E, Via Brunamonti, 51, 06100, Perugia, Italy.
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MeSH Terms
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use
Brain / pathology
Brain Ischemia / complications*,  diet therapy*,  prevention & control
Oxidative Stress / drug effects,  physiology
Stroke / diet therapy*,  etiology*,  prevention & control
Vitamin A / therapeutic use
Vitamin E / therapeutic use
Reg. No./Substance:
0/Antioxidants; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

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