Document Detail


Dietary antioxidant restriction affects the inflammatory response in athletes.
MedLine Citation:
PMID:  20003624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to determine the effects of dietary antioxidant restriction on plasma concentrations of carotenoids and inflammatory markers at rest and in response to exercise in endurance-trained males. Seventeen males performed two exercise trials 2 weeks apart. Participants followed their habitual antioxidant diet (H-AO) before the first exercise test, then a restricted antioxidant diet (R-AO) for 2 weeks before the second exercise test. Blood was collected pre- and post-exercise. Dietary intakes of fibre, ascorbic acid and beta-carotene were lower (P < 0.05) on the R-AO diet, but no other differences were observed. Pre-exercise plasma beta-carotene concentrations were lower (H-AO, 195 (sd 92); R-AO, 123 (sd 54) ng/ml; P < 0.05), and TNF-alpha concentrations were higher (H-AO, 16 (sd 7); R-AO, 613 (sd 325) pg/ml; P < 0.01) on the R-AO diet compared to the H-AO diet. Most plasma carotenoid concentrations decreased with exercise, but this effect was more consistent on the H-AO diet. No differences in plasma IL-6 concentrations were observed pre-exercise, whereas post-exercise plasma IL-6 concentrations (H-AO, 30.3 (sd 16); R-AO, 15.3 (sd 5) pg/ml; P < 0.05) were lower following the R-AO diet. Post-exercise TNF-alpha concentrations were higher on the R-AO diet. Ratings of perceived effort during submaximal exercise were higher (P < 0.05) on the R-AO diet, but there was no difference in the time to exhaustion between diets. In conclusion, lower dietary intakes of carotenoids alter the plasma concentrations of antioxidants and markers of inflammation at rest and in response to exercise.
Authors:
Brendan A Plunkett; Robin Callister; Trent A Watson; Manohar L Garg
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Publication Detail:
Type:  Journal Article     Date:  2009-12-15
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1179-84     Citation Subset:  IM    
Affiliation:
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Callaghan, 2308 NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antioxidants / pharmacology*
Athletes*
Blood Specimen Collection
Diet
Exercise Test / drug effects*
Humans
Inflammation / physiopathology*
Leukotriene B4 / blood
Male
Oxygen Consumption / drug effects
Running
Young Adult
Chemical
Reg. No./Substance:
0/Antioxidants; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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