Document Detail

Dietary antibiotic growth promoters enhance the bioavailability of alpha-tocopheryl acetate in broilers by altering lipid absorption.
MedLine Citation:
PMID:  15173416     Owner:  NLM     Status:  MEDLINE    
The influence of intestinal microbial bile salt deconjugation on absorption of fatty acids and alpha- and gamma-tocopherol was investigated in a trial with Ross 208 broilers. Birds (n = 1600) were assigned to 4 dietary treatments: no supplementation or supplementation of antibiotics (salinomycin, 40 mg/kg feed and avilamycin, 10 mg/kg feed), and inclusion of either animal fat (10 g/100 g feed) or soybean oil (10 g/100 g feed) in the diet. At d 7, 14, 21, and 35 of age, the intestinal number of the bile salt hydrolase-active bacteria Clostridium perfringens, the concentration of conjugated and unconjugated bile salts, the ileal absorption of fatty acids and tocopherols, and the blood plasma concentrations of tocopherols were measured. All variables were significantly influenced by bird age. C. perfringens counts were lower and bile salt concentrations were greater in birds fed soybean oil. The supplementation of antibiotics reduced the numbers of C. perfringens in the small intestine and reduced the concentration of unconjugated bile salts. The ileal absorption of fatty acids and alpha-tocopherol, as well as the plasma concentration of alpha-tocopherol, was greater in birds fed antibiotics. The absorption and plasma concentration of gamma-tocopherol were not influenced by antibiotics. Unlike gamma-tocopherol, which is present solely as the free alcohol, the major proportion of dietary alpha-tocopherol is present as alpha-tocopheryl acetate, which requires a bile salt-dependent enzymatic hydrolysis before absorption. In conclusion, proper digestion of lipid-soluble compounds is highly dependent on an adequate concentration of bile salts in the small intestine to provide proper lipid emulsification and activation of lipolytic enzymes.
Ane Knarreborg; Charlotte Lauridsen; Ricarda M Engberg; Søren K Jensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2004-07-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1487-92     Citation Subset:  IM    
Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, DK-8830 Tjele, Denmark.
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MeSH Terms
Aging / metabolism
Amidohydrolases / metabolism
Anti-Bacterial Agents / administration & dosage*
Bile Acids and Salts / metabolism
Biological Availability
Carboxylesterase / metabolism
Clostridium perfringens / enzymology,  isolation & purification
Colony Count, Microbial
Fatty Acids / metabolism
Ileum / metabolism
Intestinal Absorption / drug effects
Intestines / microbiology
Lipase / metabolism
Oligosaccharides / administration & dosage*
Pyrans / administration & dosage*
Tocopherols / blood,  metabolism,  pharmacokinetics
alpha-Tocopherol / analogs & derivatives*,  pharmacokinetics*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bile Acids and Salts; 0/Fatty Acids; 0/Oligosaccharides; 0/Pyrans; 11051-71-1/avilamycin; 1406-66-2/Tocopherols; 53003-10-4/salinomycin; 59-02-9/alpha-Tocopherol; EC; EC; EC 3.5.-/Amidohydrolases; EC hydrolase

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