| Dietary antibiotic growth promoters enhance the bioavailability of alpha-tocopheryl acetate in broilers by altering lipid absorption. | |
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MedLine Citation:
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PMID: 15173416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of intestinal microbial bile salt deconjugation on absorption of fatty acids and alpha- and gamma-tocopherol was investigated in a trial with Ross 208 broilers. Birds (n = 1600) were assigned to 4 dietary treatments: no supplementation or supplementation of antibiotics (salinomycin, 40 mg/kg feed and avilamycin, 10 mg/kg feed), and inclusion of either animal fat (10 g/100 g feed) or soybean oil (10 g/100 g feed) in the diet. At d 7, 14, 21, and 35 of age, the intestinal number of the bile salt hydrolase-active bacteria Clostridium perfringens, the concentration of conjugated and unconjugated bile salts, the ileal absorption of fatty acids and tocopherols, and the blood plasma concentrations of tocopherols were measured. All variables were significantly influenced by bird age. C. perfringens counts were lower and bile salt concentrations were greater in birds fed soybean oil. The supplementation of antibiotics reduced the numbers of C. perfringens in the small intestine and reduced the concentration of unconjugated bile salts. The ileal absorption of fatty acids and alpha-tocopherol, as well as the plasma concentration of alpha-tocopherol, was greater in birds fed antibiotics. The absorption and plasma concentration of gamma-tocopherol were not influenced by antibiotics. Unlike gamma-tocopherol, which is present solely as the free alcohol, the major proportion of dietary alpha-tocopherol is present as alpha-tocopheryl acetate, which requires a bile salt-dependent enzymatic hydrolysis before absorption. In conclusion, proper digestion of lipid-soluble compounds is highly dependent on an adequate concentration of bile salts in the small intestine to provide proper lipid emulsification and activation of lipolytic enzymes. |
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Authors:
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Ane Knarreborg; Charlotte Lauridsen; Ricarda M Engberg; Søren K Jensen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 134 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-02 Completed Date: 2004-07-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1487-92 Citation Subset: IM |
Affiliation:
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Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, DK-8830 Tjele, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Amidohydrolases / metabolism Animals Anti-Bacterial Agents / administration & dosage* Bile Acids and Salts / metabolism Biological Availability Carboxylesterase / metabolism Chickens Clostridium perfringens / enzymology, isolation & purification Colony Count, Microbial Diet Fatty Acids / metabolism Ileum / metabolism Intestinal Absorption / drug effects Intestines / microbiology Lipase / metabolism Oligosaccharides / administration & dosage* Pyrans / administration & dosage* Tocopherols / blood, metabolism, pharmacokinetics alpha-Tocopherol / analogs & derivatives*, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bile Acids and Salts; 0/Fatty Acids; 0/Oligosaccharides; 0/Pyrans; 11051-71-1/avilamycin; 1406-66-2/Tocopherols; 53003-10-4/salinomycin; 59-02-9/alpha-Tocopherol; EC 3.1.1.1/Carboxylesterase; EC 3.1.1.3/Lipase; EC 3.5.-/Amidohydrolases; EC 3.5.1.24/choloylglycine hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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