| Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 19491530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have shown that dietary alpha-linolenic acid (ALA) is associated with a reduced risk of cardiovascular disease and has an antihypertensive effect. Blood pressure is regulated mainly by angiotensin-converting enzyme (ACE). In the present study, we investigated the effect of dietary ALA on ACE to clarify the mechanism of the antihypertensive effect in spontaneously hypertensive rats (SHR). Six-week-old SHR were fed a diet containing either 10% ALA-rich flaxseed oil or high oleic safflower oil as a control for four weeks. Systolic blood pressure (SBP) was measured by the tail cuff method once weekly. At the end of the feeding period, ACE activity was determined in the heart, aorta, lung and kidney. ACE mRNA in these organs was also measured by real-time PCR analysis. SBP in the ALA group was significantly lower than in the control group at 2, 3, and 4 weeks. The ACE activity and mRNA expression levels in the ALA group were significantly lower than in the control only in the aorta. In conclusion, the present findings suggest that the blood pressure-lowering mechanism of dietary ALA may be involved in the reduction of ACE activity and mRNA expression levels in the aorta of SHR. |
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Authors:
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Akiko Ogawa; Yo Suzuki; Toshiaki Aoyama; Hiroyuki Takeuchi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oleo science Volume: 58 ISSN: 1347-3352 ISO Abbreviation: J Oleo Sci Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101175339 Medline TA: J Oleo Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 355-60 Citation Subset: IM |
Affiliation:
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Central Research Laboratory, The Nisshin OilliO Group, Ltd., Kanagawa, Japan. a-ogawa@nisshin-oillio.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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administration & dosage,
pharmacology* Animals Aorta / enzymology* Blood Pressure / drug effects Diet Enzyme Repression / drug effects Gene Expression Profiling Hypertension / enzymology*, genetics* Peptidyl-Dipeptidase A / genetics*, metabolism* Plant Oils / administration & dosage RNA, Messenger / genetics, metabolism Rats Rats, Inbred SHR Reverse Transcriptase Polymerase Chain Reaction Seeds / chemistry alpha-Linolenic Acid / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Plant Oils; 0/RNA, Messenger; 463-40-1/alpha-Linolenic Acid; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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