Document Detail


Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats.
MedLine Citation:
PMID:  19491530     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies have shown that dietary alpha-linolenic acid (ALA) is associated with a reduced risk of cardiovascular disease and has an antihypertensive effect. Blood pressure is regulated mainly by angiotensin-converting enzyme (ACE). In the present study, we investigated the effect of dietary ALA on ACE to clarify the mechanism of the antihypertensive effect in spontaneously hypertensive rats (SHR). Six-week-old SHR were fed a diet containing either 10% ALA-rich flaxseed oil or high oleic safflower oil as a control for four weeks. Systolic blood pressure (SBP) was measured by the tail cuff method once weekly. At the end of the feeding period, ACE activity was determined in the heart, aorta, lung and kidney. ACE mRNA in these organs was also measured by real-time PCR analysis. SBP in the ALA group was significantly lower than in the control group at 2, 3, and 4 weeks. The ACE activity and mRNA expression levels in the ALA group were significantly lower than in the control only in the aorta. In conclusion, the present findings suggest that the blood pressure-lowering mechanism of dietary ALA may be involved in the reduction of ACE activity and mRNA expression levels in the aorta of SHR.
Authors:
Akiko Ogawa; Yo Suzuki; Toshiaki Aoyama; Hiroyuki Takeuchi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  58     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  IM    
Affiliation:
Central Research Laboratory, The Nisshin OilliO Group, Ltd., Kanagawa, Japan. a-ogawa@nisshin-oillio.com
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology*
Animals
Aorta / enzymology*
Blood Pressure / drug effects
Diet
Enzyme Repression / drug effects
Gene Expression Profiling
Hypertension / enzymology*,  genetics*
Peptidyl-Dipeptidase A / genetics*,  metabolism*
Plant Oils / administration & dosage
RNA, Messenger / genetics,  metabolism
Rats
Rats, Inbred SHR
Reverse Transcriptase Polymerase Chain Reaction
Seeds / chemistry
alpha-Linolenic Acid / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Plant Oils; 0/RNA, Messenger; 463-40-1/alpha-Linolenic Acid; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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