Document Detail

Dietary advanced glycation endproducts (AGEs) and their health effects--PRO.
MedLine Citation:
PMID:  17854003     Owner:  NLM     Status:  MEDLINE    
Thermal processing of food results in the formation of various novel compounds, among others advanced glycation endproducts (AGEs). AGEs result from nonenzymatic glycation reactions between reducing sugars and free amino groups of proteins, peptides, or amino acids. Due to their potential noxious effects, alimentary AGEs are also called glycotoxins. This review provides a summary of the available evidence on the health effects of exaggerated intake of thermally treated food. Data from experimental studies in rodents and from clinical studies in healthy volunteers and in patients suffering from selected diseases in which AGEs are of pathogenetic importance (diabetes, chronic renal failure) are summarized. It is concluded that, an exaggerated intake of thermally processed foods may exert in vivo diabetogenic and nephrotoxic effects, induce low-grade inflammation, enhance oxidative stress, and promote atherosclerosis.
Katarína Sebeková; Veronika Somoza
Related Documents :
12773073 - Anaphylactic reaction to a dietary supplement containing willow bark.
11285683 - The role of natural color additives in food allergy.
21346713 - Effect of cooking loss in the assessment of vitamin intake for epidemiological data in ...
Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  51     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-12-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1079-84     Citation Subset:  IM    
Research Base of Slovak Medical University, Department of Clinical and Experimental Pharmacotherapy, Bratislava, Slovakia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetes Mellitus
Dietary Proteins / administration & dosage
Food Handling / methods
Glycosylation End Products, Advanced / administration & dosage,  adverse effects*
Hot Temperature
Insulin Resistance
Renal Insufficiency, Chronic
Reg. No./Substance:
0/Dietary Proteins; 0/Glycosylation End Products, Advanced
Comment On:
Mol Nutr Food Res. 2007 Sep;51(9):1075-8   [PMID:  17854002 ]
Comment In:
Mol Nutr Food Res. 2007 Sep;51(9):1085-90   [PMID:  17854004 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dietary advanced glycation end products--a risk to human health? A call for an interdisciplinary deb...
Next Document:  Evidence against dietary advanced glycation endproducts being a risk to human health.