Document Detail


Dietary advanced glycation endproducts (AGEs) and their health effects--PRO.
MedLine Citation:
PMID:  17854003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thermal processing of food results in the formation of various novel compounds, among others advanced glycation endproducts (AGEs). AGEs result from nonenzymatic glycation reactions between reducing sugars and free amino groups of proteins, peptides, or amino acids. Due to their potential noxious effects, alimentary AGEs are also called glycotoxins. This review provides a summary of the available evidence on the health effects of exaggerated intake of thermally treated food. Data from experimental studies in rodents and from clinical studies in healthy volunteers and in patients suffering from selected diseases in which AGEs are of pathogenetic importance (diabetes, chronic renal failure) are summarized. It is concluded that, an exaggerated intake of thermally processed foods may exert in vivo diabetogenic and nephrotoxic effects, induce low-grade inflammation, enhance oxidative stress, and promote atherosclerosis.
Authors:
Katarína Sebeková; Veronika Somoza
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  51     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-12-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1079-84     Citation Subset:  IM    
Affiliation:
Research Base of Slovak Medical University, Department of Clinical and Experimental Pharmacotherapy, Bratislava, Slovakia. katarina.sebekova@szu.sk
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus
Diet*
Dietary Proteins / administration & dosage
Food Handling / methods
Glycosylation End Products, Advanced / administration & dosage,  adverse effects*
Hot Temperature
Humans
Insulin Resistance
Mice
Rats
Renal Insufficiency, Chronic
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Glycosylation End Products, Advanced
Comments/Corrections
Comment On:
Mol Nutr Food Res. 2007 Sep;51(9):1075-8   [PMID:  17854002 ]
Comment In:
Mol Nutr Food Res. 2007 Sep;51(9):1085-90   [PMID:  17854004 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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