Document Detail

Dietary administration of tannic acid lowers plasminogen activator activity in the liver of C3H hepatoma bearing male mice.
MedLine Citation:
PMID:  11204497     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was undertaken to investigate if low-dose dietary administration of tannic acid exerts its chemopreventive activity on hepatocarcinogenesis in male C3H mice through changes of plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) or plasmin inhibition (Pl) in the liver of C3H hepatoma bearing male mice. MATERIALS AND METHODS: Tannic acid was administered in the drinking water of hepatoma bearing C3H mice, in a concentration of 0.0075% (group B), 0.015% (group C) and 0.03% (group D) for 9 months. PAA, PAI and PI were measured by spectrophotometric methods in macroscopically healthy liver regions. RESULTS: Tannic acid induced a decrease of PAA (53%) and an increase of PAIs (50%) in the livers of group D while tannic acid received mice showed a dramatic decrease in liver carcinomas incidence (0% vs 33.3% in the control group). CONCLUSION: The decrease of PAA in the liver of C3H hepatoma bearing male mice, might be correlated with the chemopreventive activity of tannic acid in hepatoma development.
I A Taitzoglou; M P Tsantarliotou; C Nepka; I Zervos; E Maltezos; D Kouretas; N A Kokolis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  14     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-02-06     Completed Date:  2001-03-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  767-71     Citation Subset:  IM    
Department of Physiology, Faculty of Veterinary Medicine, University of Thessaly, 431 00 Karditsa.
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MeSH Terms
Astringents / pharmacology*
Carcinoma, Hepatocellular / drug therapy*,  metabolism,  prevention & control
Hydrolyzable Tannins / pharmacology*
Liver / drug effects,  metabolism*
Liver Neoplasms / drug therapy*,  metabolism,  prevention & control
Mice, Inbred C3H
Plasminogen Activators / metabolism*
Urokinase-Type Plasminogen Activator / metabolism
Reg. No./Substance:
0/Astringents; 0/Hydrolyzable Tannins; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

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