| Dietary acrylamide and risk of renal cell cancer. | |
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MedLine Citation:
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PMID: 14999788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The detection of acrylamide, classified as a probable human carcinogen, in commonly consumed foods created public health alarm. Thus far, only 2 epidemiologic studies have examined the effect of dietary acrylamide on cancer risk. Presently, we reanalyzed data from a large population-based Swedish case-control study of renal cell cancer. Food frequency data were linked with national food databases on acrylamide content, and daily acrylamide intake was estimated for participants. The risk of renal cell cancer was evaluated for intake of food items with elevated acrylamide levels and for total daily acrylamide dose. Adjusting for potential confounders, there was no evidence that food items with elevated acrylamide, including coffee (OR(highest vs. lowest quartile) = 0.7; 95% CI = 0.4-1.1), crisp breads (OR(highest vs. lowest quartile) = 1.0; 95% CI = 0.6-1.6) and fried potatoes (OR(highest vs. lowest quartile) = 1.1; 95% CI = 0.7-1.7), were associated with a higher risk of renal cell cancer risk. Furthermore, there was no association between estimated daily acrylamide intake through diet and cancer risk (OR(highest vs. lowest quartile) = 1.1; 95% CI = 0.7-1.8; p for trend = 0.8). The results of this study are in line with the 2 previous studies examining dietary acrylamide and suggest there is no association between dietary acrylamide and risk of renal cell cancer. |
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Authors:
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Lorelei A Mucci; Per Lindblad; Gunnar Steineck; Hans-Olov Adami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 109 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-03-04 Completed Date: 2004-04-27 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 774-6 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. lmucci@hsph.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamide
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administration & dosage,
adverse effects* Adult Aged Carcinogens / administration & dosage, adverse effects* Carcinoma, Renal Cell / chemically induced*, epidemiology Case-Control Studies Confidence Intervals Female Food Habits* Humans Kidney Neoplasms / chemically induced*, epidemiology Male Middle Aged Odds Ratio Risk Assessment Risk Factors Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 79-06-1/Acrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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