Document Detail

Dietary acid load and risk of hypertension: the Rotterdam Study.
MedLine Citation:
PMID:  22552032     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP).
DESIGN: The analyses included 2241 participants aged ≥55 y who were free of hypertension at baseline (1990-1993) and who had complete dietary and BP data. Dietary data were obtained from a 170-item food-frequency questionnaire. We used 2 measures to characterize dietary acid load: (1) potential renal acid load (PRAL) by using an algorithm including protein, phosphorus, potassium, calcium, and magnesium, and (2) estimated net endogenous acid production (NEAP) based on protein and potassium. HRs for 6-y incidence of hypertension were obtained in tertiles of PRAL and NEAP with adjustment for age, sex, BMI, smoking, education, and intakes of alcohol, fiber, and total energy.
RESULTS: We identified 1113 incident cases of hypertension during 8707 person-years of follow-up. The median dietary acid load ranged from -14.6 to 19.9 mEq/d across categories of PRAL. Hypertension risk was not significantly associated with dietary acid load. The multivariate HRs (95% CIs) in consecutive tertiles of PRAL were 1.00 (reference), 1.01 (0.87, 1.17), and 1.02 (0.88, 1.18) (P trend = 0.83). The median dietary acid loads were 30.4, 36.7, and 43.7 mEq/d, respectively, in consecutive tertiles of NEAP. Corresponding HRs for NEAP were 1.00 (reference), 0.92 (0.80, 1.07), and 0.94 (0.81, 1.10) (P-trend = 0.46).
CONCLUSION: The findings from this prospective cohort study provided no evidence of an association between dietary acid load and risk of hypertension in older adults.
Marielle F Engberink; Stephan J L Bakker; Elizabeth J Brink; Marleen A van Baak; Frank J A van Rooij; Albert Hofman; Jacqueline C M Witteman; Johanna M Geleijnse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-02
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  95     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-07-27     Revised Date:  2012-11-16    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1438-44     Citation Subset:  AIM; IM    
Top Institute Food and Nutrition, Wageningen, Netherlands.
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MeSH Terms
Acidosis / complications*,  metabolism
Acids / metabolism*
Biological Markers / metabolism
Diet Surveys
Dietary Proteins / pharmacology*
Follow-Up Studies
Hypertension / epidemiology*,  etiology,  metabolism
Kidney / metabolism
Middle Aged
Minerals / pharmacology*
Prospective Studies
Reference Values
Risk Factors
Reg. No./Substance:
0/Acids; 0/Biological Markers; 0/Dietary Proteins; 0/Minerals
Comment In:
Am J Clin Nutr. 2012 Oct;96(4):942-3; author reply 943-4   [PMID:  22996624 ]

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