| Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. | |
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MedLine Citation:
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PMID: 19923390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological evidence has associated dietary trans fatty acids (TFA) with heart disease. TFA are primarily from hydrogenated fats rich in elaidic acid, but dairy products also contain naturally occurring TFA such as vaccenic acid. Our purpose in this study was to compare the effects of consuming a commercially hydrogenated vegetable shortening rich in elaidic TFA (18:1t9) or a butter rich in vaccenic TFA (18:1t11) in the absence and presence of dietary cholesterol on atherosclerosis. LDL receptor deficient (LDLr(-/-)) mice were fed 1 of 8 experimental diets for 14 wk with the fat content replaced by: regular (pork/soy) fat (RG), elaidic shortening (ES), regular butter (RB), vaccenic butter (VB), or an atherogenic diet containing 2% cholesterol with RG (CH+RG), ES (CH+ES), RB (CH+RB), or VB (CH+VB). Serum cholesterol levels were elevated with cholesterol feeding (P < 0.001), whereas serum triglyceride levels were higher only in the CH+RB (P < 0.001) and CH+VB (P < 0.001) groups compared with the other 6 groups. Serum cholesterol and triglyceride levels were significantly lower in the CH+VB group than in the CH+RB group (P < 0.001). Atherosclerosis was stimulated by dietary ES compared with RG (P = 0.021), but CH+ES did not stimulate atherosclerosis beyond CH+RG alone. In contrast, VB did not induce an increase in atherosclerotic plaque formation compared with the RG and RB diets and the CH+VB diet reduced atherosclerosis compared with the other diets containing cholesterol (P < 0.01). In summary, consuming a hydrogenated elaidic acid-rich diet stimulates atherosclerosis, whereas a vaccenic acid-rich butter protects against atherosclerosis in this animal model. |
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Authors:
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Chantal M C Bassett; Andrea L Edel; Amanda F Patenaude; Richelle S McCullough; David P Blackwood; P Yvan Chouinard; Paul Paquin; Benoît Lamarche; Grant N Pierce |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-18 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-21 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 18-24 Citation Subset: IM |
Affiliation:
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Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine and Pharmacy, University of Manitoba, Winnipeg R2H 2A6, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / administration & dosage, pharmacology* Aorta Cholesterol / blood Diet* Dietary Fats / metabolism Eating Female Mice Mice, Inbred C57BL Mice, Knockout Oleic Acids / administration & dosage, pharmacology* Receptors, LDL / genetics*, metabolism* Triglycerides / blood Weight Gain |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Dietary Fats; 0/Oleic Acids; 0/Receptors, LDL; 0/Triglycerides; 143-25-9/11-octadecenoic acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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