| Dietary ungerminated and germinated soybean supplementation improves bone mineralization and strength in growing male rats. | |
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MedLine Citation:
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PMID: 20438320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been thought that soybean products rich in phytoestrogenic isoflavones are effective in promoting bone metabolism in ovariectomized rats. However, it is not clear if such an effect can be changed by germination of soybean and can be observed in growing males. The present study was undertaken to determine the effects of different concentrations of dietary ungerminated and germinated soybean (UGS and GS, respectively) on bone metabolism in young male rats. Forty-nine 6-week-old male Sprague-Dawley rats were assigned to seven dietary treatment groups: AIN 93G (control); control with UGS powder at 3% (UGS-L), 15% (UGS-M), or 30% (UGS-H); and control with GS powder at 3% (GS-L), 15% (GS-M), or 30% (GS-H). The biomarkers of bone metabolism (plasma and urinary Ca and P) and the physical properties and mineral content of bones were measured. Plasma osteocalcin and urinary deoxypyridinoline levels were not affected by soybean diets. The plasma P level was significantly elevated by dietary soybeans (P < .001). However, there was a negative correlation (r = -0.555) between plasma P level and dietary UGS level (P < .01). Between the UGS and GS groups, the P level of the GS-M group was significantly higher than that of the UGS-M group (P < .001). The tibial weight was decreased with low to medium doses of soybeans, but not with higher levels. Femoral bone strength was improved in the UGS-H, GS-M, and GS-H groups. The P contents of femoral and tibial bones were increased in all UGS groups as well as in GS-M and GS-H groups. In conclusion, soybean supplementation in young growing male rats improved bone mineralization and bone strength. |
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Authors:
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Heeok Hong; Woo Jung Kim; Sang Ho Yoo; Oliver D Abanto; Tae Jin Kim; Young Jin Kim; Byung Moon Jung; Sung Seob Yun; Seong-Gu Hwang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-08-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 640-9 Citation Subset: IM |
Affiliation:
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Department of Food Service Management, Sangmyung University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Development / drug effects Bone and Bones / drug effects, metabolism Calcification, Physiologic / drug effects* Dietary Supplements / analysis* Germination Humans Male Models, Animal Osteocalcin / blood Plant Preparations / administration & dosage* Random Allocation Rats Rats, Sprague-Dawley Soybeans / chemistry*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Plant Preparations; 104982-03-8/Osteocalcin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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