| Dietary Type and Amount of Fat Modulate Lipid Metabolism Gene Expression in Liver and in Adipose Tissue in Rats Fed a High-fat Diet. | |
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MedLine Citation:
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PMID: 22023986 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Dietary fat plays a central role in the development of obesity. However, the metabolic consequences of dietary fat can vary depending on their fatty acid composition. Therefore, the aim of the present work was to study the effect of the type and amount of dietary fat on the expression of genes controlling lipogenesis and fatty acid oxidation in the liver or adipose tissue of rats. METHODS: The expression of hepatic or adipose tissue lipid metabolic genes from Sprague Dawley or Zucker(fa/fa) rats, respectively, was measured after chronic consumption of diets containing different types/amount of dietary fats or after rats were adapted for 2 months to a high-fat Western diet and then fed different types and amount of fats. RESULTS: Each fat or oil in the diet regulated differentially the expression of transcription factors involved in lipogenesis and fatty acid oxidation as well as some of its target genes in liver. The expression of these genes after a chronic consumption of a high-fat Western diet was reestablished in the presence of less dietary fat and was dependent on the type of fat. In obese Zucker(fa/fa) rats, consumption of a high-fat diet repressed the expression of lipogenic, fatty acid oxidation and thermogenic genes in adipose tissue. CONCLUSIONS: Type of fat influences the expression of genes that are involved in lipid metabolism in liver and adipose tissue, but this response is repressed when the amount of dietary fat is excessive, diminishing the differences between each type of fat. |
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Authors:
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Armando R Tovar; Andrea Díaz-Villaseñor; Natally Cruz-Salazar; Guillermo Ordáz; Omar Granados; Berenice Palacios-González; Claudia Tovar-Palacio; Patricia López; Nimbe Torres |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-21 |
Journal Detail:
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Title: Archives of medical research Volume: - ISSN: 1873-5487 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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