| Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets. | |
| | |
MedLine Citation:
|
PMID: 21942754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Arginine plays an important role in preventing intestinal dysfunction and metabolic disorders caused by early weaning stress. However, little is known about how arginine mitigates early weaning stress. This study was conducted to evaluate the effects of weaning stress and dietary arginine supplementation on the metabonome in serum of piglets using 1H nuclear magnetic resonance spectroscopy in conjunction with multivariate data analysis. Thirty castrated male piglets aged 21 d were evenly divided into three groups and fed in three different regimes: sow-fed (SF), weaned with L-alanine supplementation (ALA) and weaned with arginine supplementation (ARG). We found that early weaning stress led to a significantly reduced bodyweight gain (15.6%) and that supplementation with arginine can improve growth rates in piglets by 5.6% (P < 0.05). The early weaning stress was associated with marked alterations in lipid and amino acid metabolisms and perturbations in population and/or activities of gut microorganisms, which were manifested in increased levels of organic acids, amino acids and acetyl-glycoproteins and reduced levels of choline metabolism and lipoproteins. Dietary supplementation with arginine could partially counteract the changes of metabolites induced by weaning stress, such as lipid and amino acid metabolisms. However, arginine was not able to restore disturbed gut microbiota. These results demonstrate the central role of arginine supplementation in regulating the metabolisms of weaned piglets. |
| | |
Authors:
|
Qinghua He; Huiru Tang; Pingping Ren; Xiangfeng Kong; Guoyao Wu; Yulong Yin; Yulan Wang |
Related Documents
:
|
18505264 - Dichloromethane as a solvent for lipid extraction and assessment of lipid classes and f... 10919364 - Percutaneous penetration of ozagrel and the enhancement produced by saturated fatty acids. 9109374 - Do specific linoleate 13-lipoxygenases initiate beta-oxidation? 15497464 - Odd-numbered long-chain fatty acids in erythrocyte phospholipids as long-term follow-up... 19626354 - Optimization of medium components for high-molecular-weight hyaluronic acid production ... 8389634 - Functional analysis of apf1 mutation causing defective amino acid transport in saccharo... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-27 |
Journal Detail:
|
Title: Journal of proteome research Volume: - ISSN: 1535-3907 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased mean platelet volume in primary Raynaud's phenomenon.
Next Document: Bladder Neck Plication Stitch: A Novel Technique During Robot-Assisted Radical Prostatectomy to Impr...