Document Detail


Dietary supplementation with carotenoids improves immunity without increasing its cost in a crustacean.
MedLine Citation:
PMID:  20540610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Costs of immunity include self-harming autoreactivity through the production of cytotoxic chemicals. While carotenoids stimulate immunity and reduce oxidative stress during immune activity in vertebrates, their involvement in invertebrate immunity is unclear. Recently, a positive correlation between immune defenses and concentration of carotenoids in the hemolymph was demonstrated in the crustacean Gammarus pulex, suggesting an important role of carotenoids in invertebrate immunity. We tested the causality of this relationship by using a dietary supplementation with carotenoids and measuring several immune parameters. We found that dietary carotenoids had a broad immunostimulating effect, enhancing phenoloxidase activity and resistance to a bacterial infection. When immune challenged, gammarids fed with carotenoids did not pay an additional survival cost because of autoreactivity, despite their intensified immune activity. Therefore, dietary carotenoids improved gammarids' immunity without inducing additional self-harming. This underlines the importance of carotenoids in both the regulation and the evolution of immunity in G. pulex.
Authors:
Aurélie Babin; Clotilde Biard; Yannick Moret
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American naturalist     Volume:  176     ISSN:  1537-5323     ISO Abbreviation:  Am. Nat.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984688R     Medline TA:  Am Nat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-41     Citation Subset:  IM    
Affiliation:
Equipe Ecologie Evolutive, Unité Mixte de Recherche, Centre National de la Recherche Scientifique 5561 Biogéosciences, Université de Bourgogne, F-21000 Dijon, France.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology*
Amphipoda / drug effects,  immunology*,  microbiology
Animals
Carotenoids / pharmacology*
Immunity, Innate / drug effects*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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