| Dietary restraint violations influence reward responses in nucleus accumbens and amygdala. | |
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MedLine Citation:
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PMID: 20807052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous studies have demonstrated that consuming high-calorie food leads to subsequent overeating by chronic dieters. The present study investigates the neural correlates of such self-regulatory failures using fMRI. Chronic dieters (n = 50) and non-dieters (n = 50) consumed either a 15-oz glass of cold water or a 15-oz milkshake and were subsequently imaged while viewing pictures of animals, environmental scenes, people, and appetizing food items. Results revealed a functional dissociation in nucleus accumbens and amygdala activity that paralleled well-established behavioral patterns of eating observed in dieters and non-dieters. Whereas non-dieters showed the greatest nucleus accumbens activity in response to food items after water consumption, dieters showed the greatest activity after consuming the milkshake. Activity in the left amygdala demonstrated the reverse interaction. Considered together with previously reported behavioral findings, the present results offer a suggested neural substrate for diet failure. |
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Authors:
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Kathryn E Demos; William M Kelley; Todd F Heatherton |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-31 |
Journal Detail:
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Title: Journal of cognitive neuroscience Volume: 23 ISSN: 1530-8898 ISO Abbreviation: J Cogn Neurosci Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-01 Completed Date: 2011-09-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8910747 Medline TA: J Cogn Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1952-63 Citation Subset: IM |
Affiliation:
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Dartmouth College, USA. kathryn_demos@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amygdala / blood supply, physiology* Analysis of Variance Animals Brain Mapping Caloric Restriction* Eating / physiology* Female Humans Image Processing, Computer-Assisted Imagination / physiology Male Nucleus Accumbens / blood supply, physiology* Oxygen / blood Photic Stimulation Reaction Time / physiology Reward* Visual Perception / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DA022582/DA/NIDA NIH HHS; R01 DA022582-01/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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