Document Detail


Dietary restraint violations influence reward responses in nucleus accumbens and amygdala.
MedLine Citation:
PMID:  20807052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous studies have demonstrated that consuming high-calorie food leads to subsequent overeating by chronic dieters. The present study investigates the neural correlates of such self-regulatory failures using fMRI. Chronic dieters (n = 50) and non-dieters (n = 50) consumed either a 15-oz glass of cold water or a 15-oz milkshake and were subsequently imaged while viewing pictures of animals, environmental scenes, people, and appetizing food items. Results revealed a functional dissociation in nucleus accumbens and amygdala activity that paralleled well-established behavioral patterns of eating observed in dieters and non-dieters. Whereas non-dieters showed the greatest nucleus accumbens activity in response to food items after water consumption, dieters showed the greatest activity after consuming the milkshake. Activity in the left amygdala demonstrated the reverse interaction. Considered together with previously reported behavioral findings, the present results offer a suggested neural substrate for diet failure.
Authors:
Kathryn E Demos; William M Kelley; Todd F Heatherton
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-31
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  23     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-06-01     Completed Date:  2011-09-23     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1952-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amygdala / blood supply,  physiology*
Analysis of Variance
Animals
Brain Mapping
Caloric Restriction*
Eating / physiology*
Female
Humans
Image Processing, Computer-Assisted
Imagination / physiology
Male
Nucleus Accumbens / blood supply,  physiology*
Oxygen / blood
Photic Stimulation
Reaction Time / physiology
Reward*
Visual Perception / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
DA022582/DA/NIDA NIH HHS; R01 DA022582/DA/NIDA NIH HHS; R01 DA022582-01/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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