Document Detail

Dietary protein level interacts with omega-3 polyunsaturated fatty acid deficiency to induce hypertension.
MedLine Citation:
PMID:  19893499     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dietary omega-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids.
METHODS: Female rats were placed on one of four experimental diets 1 week prior to mating. Diets were either deficient (10% safflower oil; DEF) or sufficient (7% safflower oil, 3% flaxseed oil; SUF) in omega-3 fatty acids and contained 20 or 30% casein (DEF20, SUF20, DEF30, SUF30). Offspring were maintained on the maternal diet for the duration of the experiment. At 12, 18, 24, and 30 weeks, blood pressure was assessed by tail cuff plethysmography.
RESULTS: At both 12 and 18 weeks of age, no differences in blood pressure were observed based on diet, however, by 24 weeks hypertension was evident in DEF30 animals; there were no blood pressure differences between the other groups. This hypertension in DEF30 group was increased at 30 weeks, with systolic, diastolic, and mean arterial pressure all elevated.
CONCLUSIONS: These results indicate that the hypertension previously attributed to omega-3 fatty acid deficiency is dependent on additional dietary factors, including protein content. Furthermore, this study is the first to plot the establishment of omega-3 fatty acid deficiency hypertension over time.
Denovan P Begg; Andrew J Sinclair; Lauren A Stahl; Manohar L Garg; Mark Jois; Richard S Weisinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-05
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-09     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
School of Medicine, Deakin University, Geelong, Australia.
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MeSH Terms
Aging / physiology
Blood Pressure / drug effects
Caseins / pharmacology
Dietary Proteins / adverse effects*
Fatty Acids, Omega-3 / metabolism*
Heart Rate / drug effects
Hypertension / etiology*,  physiopathology
Rats, Sprague-Dawley
Reg. No./Substance:
0/Caseins; 0/Dietary Proteins; 0/Fatty Acids, Omega-3
Comment In:
Am J Hypertens. 2010 Feb;23(2):111-2   [PMID:  20087325 ]

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