| Dietary phosphorus restriction in advanced chronic kidney disease: merits, challenges, and emerging strategies. | |
| | |
MedLine Citation:
|
PMID: 20557490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperphosphatemia is an independent risk factor for mortality in patients on maintenance dialysis. Since phosphorus clearance by standard three times-weekly dialysis is insufficient to balance ongoing dietary phosphorus intake, strategies to prevent absorption of dietary phosphorus are essential for attenuating increased serum levels. Dietary phosphorus binders are used widely for this purpose but dietary phosphorus restriction is relatively underutilized, most likely because of the logistical complexity of instituting and monitoring a low phosphorus diet, and for fear of worsening protein-energy wasting, which itself is a potent risk factor for mortality. In this review, we propose sustainable strategies for reducing phosphorus intake while avoiding exacerbation of protein-energy wasting. The approach is based on recognition of the dissociation between protein and phosphorus content in phosphorus-rich processed foods and the varying phosphorus bioavailability in different dietary sources. Controlling serum phosphate levels is among the most challenging aspects of day-to-day dialysis care but integration of sensible dietary interventions will likely improve phosphorus control. |
| | |
Authors:
|
Orlando M Gutiérrez; Myles Wolf |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-06-14 |
Journal Detail:
|
Title: Seminars in dialysis Volume: 23 ISSN: 1525-139X ISO Abbreviation: Semin Dial Publication Date: 2010 Jul-Aug |
Date Detail:
|
Created Date: 2010-08-12 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8911629 Medline TA: Semin Dial Country: United States |
Other Details:
|
Languages: eng Pagination: 401-6 Citation Subset: IM |
Affiliation:
|
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Hyperphosphatemia / etiology, prevention & control* Kidney Failure, Chronic / blood, complications, diet therapy* Phosphorus, Dietary / administration & dosage, adverse effects*, pharmacokinetics Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Phosphorus, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary sodium in chronic kidney disease: a comprehensive approach.
Next Document: Trace element status in hemodialysis patients.