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A Dietary Pattern Associated with LINE-1 Methylation Alters the Risk of Developing Cervical Intraepithelial Neoplasia.
MedLine Citation:
PMID:  22262813     Owner:  NLM     Status:  Publisher    
There is a paucity of research examining the relationships between dietary patterns (DPs) and risk of developing pre-cancerous lesions as well as biomarkers associated with such DPs. The purpose of the current study was to identify DPs that are associated with higher grades of cervical intraepithelial neoplasia (CIN 2+) and to determine whether these DPs are associated with the degree of DNA methylation in the long interspersed nucleotide elements (L1s) of peripheral blood mononuclear cells (PBMCs), a biomarker associated with risk of developing CIN 2+. Study population consisted of 319 child-bearing age women. DPs were derived by factor analysis. The degree of PBMC L1 methylation was assessed by pyrosequencing. Logistic regression models were used to evaluate the associations between DPs and CIN 2+. Similar models were used to evaluate the association between DPs and degree of PBMC L1 methylation in women free of CIN 2+. Women with the unhealthiest DP were 3.5 times more likely to be diagnosed with CIN 2+ compared to women with the healthiest DP (OR=3.5; 95% CI, 1.2-10.1; P=0.02). Women at risk for developing CIN 2+ with the healthiest DP were 3.3 times more likely to have higher PBMC L1 methylation compared to women with the unhealthiest DP (OR=3.3; 95% CI, 1.0-10.6; P=0.04). Our findings suggest that HPV associated risk of developing CIN 2+ may be reduced by improving DPs. The degree of PBMC L1 methylation may serve as a biomarker for monitoring the effectiveness of dietary modifications needed for reducing the risk of CIN 2+.
Chandrika J Piyathilake; Suguna Badiga; Edmond Kabagambe; Andres Azuero; Ronald D Alvarez; Gary L Johanning; Edward E Partridge
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  -     ISSN:  1940-6215     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Nutrition Sciences, University of Alabama at Birmingham.
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