| Dietary nucleotide supplements in infant formula modify the expression of P-glycoprotein in the intestinal epithelium in vitro. | |
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MedLine Citation:
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PMID: 20533224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dietary nucleotides at concentrations found in supplemented infant formula on P-glycoprotein (P-gp) expression in colon cells was examined. We report that P-gp expression in colon cells was significantly decreased in a time- and concentration-dependent manner. When colon cells were co-cultured with lymphocytes, so as to mimic the involvement of gut-associated lymphoid tissue in normal gut pathophysiology, we observed a reversal of this effect with a demonstrated increase in P-gp expression. These findings have important implications on effects of nucleotide exposure on increasing drug bioavailability, reducing the capacity for xenobiotic efflux, and increasing the risk of inflammatory bowel disease in susceptible infants. Future studies are directed at defining both the mechanisms underlying these findings and effects of dietary nucleotide supplementation in vivo. |
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Authors:
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Mary Bebawy; Christine Rasmussen; Shwetha Sambasivam; Shisan Bao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 79 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 381-7 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, Sydney University, Australia. maryb@pharm.usyd.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Cell Line, Tumor Dietary Supplements Gastrointestinal Tract / drug effects*, metabolism Humans Infant Infant Formula* Inflammatory Bowel Diseases / metabolism, prevention & control Intestinal Mucosa / drug effects*, metabolism Nucleotides / administration & dosage* P-Glycoprotein / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Nucleotides; 0/P-Glycoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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