| Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats. | |
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MedLine Citation:
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PMID: 20099884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Milk fat globule membrane (MFGM) is a biopolymer composed primarily of membrane proteins and lipids that surround the fat globules in milk. Although it is considered to have potential as a bioactive ingredient, few feeding studies have been conducted to measure its potential benefits. The aim of this investigation was to determine if dietary MFGM confers protection against colon carcinogenesis compared to diets containing corn oil (CO) or anhydrous milk fat (AMF). Male, weanling Fischer-344 rats were randomly assigned to one of three dietary treatments that differed only in the fat source: (1) AIN-76A diet, corn oil; (2) AIN-76A diet, AMF; and (3) AIN-76A diet, 50% MFGM, 50% AMF. Each diet contained 50 g/kg diet of fat. With the exception of the fat source, diets were formulated to be identical in macro and micro nutrient content. Animals were injected with 1,2-dimethylhydrazine once per week at weeks 3 and 4, and fed experimental diets for a total of 13 weeks. Over the course of the study dietary treatment did not affect food consumption, weight gain or body composition. After 13 weeks animals were sacrificed, colons were removed and aberrant crypt foci (ACF) were counted by microscopy. Rats fed the MFGM diet (n = 16) had significantly fewer ACF (20.9 +/- 5.7) compared to rats fed corn oil (n = 17) or AMF (n = 16) diets (31.3 +/- 9.5 and 29.8 +/- 11.4 respectively; P < 0.05). Gene expression analysis of colonic mucosa did not reveal differential expression of candidate colon cancer genes, and the sphingolipid profile of the colonic mucosa was not affected by diet. While there were notable and significant differences in plasma and red blood cell lipids, there was no relationship to the cancer protection. These results support previous findings that dietary sphingolipids are protective against colon carcinogenesis yet extend this finding to MFGM, a milk fat fraction available as a food ingredient. |
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Authors:
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Dallin R Snow; Rafael Jimenez-Flores; Robert E Ward; Jesse Cambell; Michael J Young; Ilka Nemere; Korry J Hintze |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 2157-63 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Dietetics and Food Sciences, Utah State University, 750 N 1200 E, Logan, Utah 84322-8700, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Cattle Choristoma / prevention & control* Colonic Neoplasms / epidemiology, prevention & control* Corn Oil / pharmacology Glycolipids / isolation & purification, pharmacology*, therapeutic use Glycoproteins / isolation & purification, pharmacology*, therapeutic use Incidence Male Milk Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Glycolipids; 0/Glycoproteins; 0/milk fat globule; 8001-30-7/Corn Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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