| Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. | |
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MedLine Citation:
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PMID: 21346062 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In preclinical reports, restriction of dietary methionine intake was shown to enhance metabolic flexibility, improve lipid profiles, and reduce fat deposition. The present report is the outcome of a "proof of concept" study to evaluate the efficacy of dietary methionine restriction (MR) in humans with metabolic syndrome. METHODS: Twenty-six obese subjects (six male and 20 female) meeting criteria for metabolic syndrome were randomized to a diet restricted to 2 mg methionine/kg body weight per day and were provided capsules containing either placebo (n = 12) or 33 mg methionine/kg body weight per day (n = 14). Energy expenditure, body composition, insulin sensitivity, and biomarkers of metabolic syndrome were measured before and after 16 wk on the respective diets. RESULTS: Insulin sensitivity and biomarkers of metabolic syndrome improved comparably in both dietary groups. Rates of energy expenditure were unaffected by the diets, but dietary MR produced a significant increase in fat oxidation (MR, 12.1 ± 6.0% increase; control, 8.1 ± 3.3% decrease) and reduction in intrahepatic lipid content (MR liver/spleen attenuation ratio, 8.1 ± 3.3% increase; control ratio, 2.2 ± 2.1% increase) that was independent of the comparable reduction in weight and adiposity that occurred in both groups. CONCLUSIONS: Sixteen weeks of dietary MR in subjects with metabolic syndrome produced a shift in fuel oxidation that was independent of the weight loss, decreased adiposity, and improved insulin sensitivity that was common to both diets. |
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Authors:
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Eric P Plaisance; Frank L Greenway; Anik Boudreau; Kasey L Hill; William D Johnson; Rozlyn A Krajcik; Carmen E Perrone; Norman Orentreich; William T Cefalu; Thomas W Gettys |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-23 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-05 Completed Date: 2011-06-30 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E836-40 Citation Subset: AIM; IM |
Affiliation:
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Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00640757 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism* Biological Markers / blood Body Composition / physiology Cohort Studies Cystine / blood Diet* Dietary Fats / metabolism Double-Blind Method Energy Metabolism / physiology Fats / metabolism* Female Glucose / metabolism Humans Insulin Resistance / physiology Kinetics Liver / metabolism Male Metabolic Syndrome X / metabolism* Methionine / blood, pharmacology* Middle Aged Obesity / metabolism* Oxidation-Reduction Waist Circumference / physiology |
| Grant Support | |
ID/Acronym/Agency:
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1P30 DK072476/DK/NIDDK NIH HHS; P20-RR021945/RR/NCRR NIH HHS; P50AT002776-01/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Fats; 50-99-7/Glucose; 56-89-3/Cystine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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