| Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. | |
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MedLine Citation:
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PMID: 20616616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer. METHODS: We examined the significance of HMGB1 in causing colon carcinogenesis induced by azoxymethane (AOM) injection in Fischer 344 rats fed on a control diet (group C), a 15% linoleic acid (LA) diet (group L), a control diet with 10% glucose drink (group G), and a 15% LA diet with a 10% glucose drink (group L+G). RESULTS: Group L+G showed the highest body weight and calorie intake. Serum and mucosal HMGB1 levels were temporally increased in all groups, while the highest levels were observed in group L+G. Mucosal HMGB1 levels were correlated with cancer multiplicity and nodal metastases. In the AOM-injected rats fed the 15% LA diet with 10% glucose drink, administration of HMGB1 antibody suppressed serum HMGB1 concentration and cancer multiplicity. CONCLUSION: These data suggest that dietary LA and glucose provided the synergistic effect on AOM-induced rat colon cancer through HMGB1 induction. |
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Authors:
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Hitoshi Ohmori; Yi Luo; Kiyomu Fujii; Tomonori Sasahira; Takasumi Shimomoto; Ayumi Denda; Hiroki Kuniyasu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-07 |
Journal Detail:
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Title: Pathobiology : journal of immunopathology, molecular and cellular biology Volume: 77 ISSN: 1423-0291 ISO Abbreviation: Pathobiology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007504 Medline TA: Pathobiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 210-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Pathology, Nara Medical University, Kashihara, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Azoxymethane / metabolism, pharmacology, toxicity* Carcinogens / toxicity* Colonic Neoplasms / chemically induced*, metabolism*, pathology Diet Drug Synergism Glucose / adverse effects, metabolism, pharmacology HMGB1 Protein / adverse effects, metabolism*, pharmacology Linoleic Acid / administration & dosage, adverse effects*, metabolism, pharmacology Male Random Allocation Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/HMGB1 Protein; 2197-37-7/Linoleic Acid; 25843-45-2/Azoxymethane; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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