| Dietary L-carnitine supplementation in obese cats alters carnitine metabolism and decreases ketosis during fasting and induced hepatic lipidosis. | |
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MedLine Citation:
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PMID: 11823579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to determine whether dietary carnitine supplement could protect cats from ketosis and improve carnitine and lipid metabolism in experimental feline hepatic lipidosis (FHL). Lean spayed queens received a diet containing 40 (CL group, n = 7) or 1000 (CH group, n = 4) mg/kg of L-carnitine during obesity development. Plasma fatty acid, beta-hydroxybutyrate and carnitine, and liver and muscle carnitine concentrations were measured during experimental induction of FHL and after treatment. In control cats (CL group), fasting and FHL increased the plasma concentrations of fatty acids two- to threefold (P < 0.0001) and beta-hydroxybutyrate > 10-fold (from a basal 0.22 +/- 0.03 to 1.70 +/- 0.73 after 3 wk fasting and 3.13 +/- 0.49 mmol/L during FHL). In carnitine-supplemented cats, these variables increased significantly (P < 0.0001) only during FHL (beta-hydroxybutyrate, 1.42 +/- 0.17 mmol/L). L-Carnitine supplementation significantly increased plasma, muscle and liver carnitine concentrations. Liver carnitine concentration increased dramatically from the obese state to FHL in nonsupplemented cats, but not in supplemented cats, which suggests de novo synthesis of carnitine from endogenous amino acids in control cats and reversible storage in supplemented cats. These results demonstrate the protective effect of a dietary L-carnitine supplement against fasting ketosis during obesity induction. Increasing the L-carnitine level of diets in cats with low energy requirements, such as after neutering, and a high risk of obesity could therefore be recommended. |
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Authors:
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Géraldine Blanchard; Bernard M Paragon; Fabien Milliat; Claude Lutton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 132 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-01 Completed Date: 2002-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 204-10 Citation Subset: IM |
Affiliation:
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UP de Nutrition, Ecole Nationale Vétérinaire d'Alfort, 94704 Maisons Alfort, France. blanchard@vet-alfort.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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blood Animals Carnitine / administration & dosage, metabolism*, pharmacology Cat Diseases / metabolism, prevention & control* Cats Dietary Supplements Fasting Fatty Acids / blood Female Ketosis / metabolism, prevention & control, veterinary* Lipid Metabolism* Lipidoses / chemically induced, metabolism, veterinary* Liver / chemistry, metabolism Muscle, Skeletal / chemistry, metabolism Obesity / metabolism, veterinary* Random Allocation Specific Pathogen-Free Organisms |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 300-85-6/3-Hydroxybutyric Acid; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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