Document Detail

Dietary L-arginine restores aspirin-induced endothelial dysfunction in rat aorta.
MedLine Citation:
PMID:  14972745     Owner:  NLM     Status:  MEDLINE    
L-Arginine induced elevation of the vascular prostanoid led us to think that the risk of coronary spasm may increase in L-arginine consumers when they are subjected to cyclooxygenase inhibitors and this limits the therapeutic value of aspirin. So the aim was to investigate the interaction of aspirin and dietary L-arginine in male rats. Animals were divided into four groups and fed with normal food. The first group received tap water while the second, third and fourth groups were subjected daily to aspirin (8.6 mg/kg), L-arginine (143 mg/kg) and aspirin + L-arginine combination in their drinking water respectively for 7 days. Vasomotor responses were recorded in the aortic rings suspended for isometric-force recordings. Aspirin treatment significantly reduced the dilation to acetylcholine and sodium nitroprusside. Attenuated phenylephrine contractility was associated with normal acetylcholine response in L-arginine group. Addition of L-arginine to aspirin treatment completely prevented aspirin-induced endothelial dysfunction but defective response to sodium nitroprusside persisted. Dietary L-arginine without affecting maximal dilation to acetylcholine significantly increased the share of dilator prostanoid which appears to resist aspirin. These results demonstrated that dietary L-arginine increases dilator prostaoid in rat aortic rings. Contrary to our expectation, co-administered L-arginine protected aspirin induced endothelial dysfunction and ruled out the limitation of aspirin use in L-arginine consumers.
I Bilgen; G Oner; E Eren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  111     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  232-8     Citation Subset:  IM    
Department of Physiology, Akdeniz University Medical Faculty, Antalya, Turkey.
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MeSH Terms
Acetylcholine / pharmacology
Animal Feed
Aorta, Thoracic / drug effects,  metabolism,  physiopathology
Arginine / pharmacology*
Aspirin / pharmacology,  toxicity*
Dose-Response Relationship, Drug
Drug Interactions
Endothelium, Vascular / drug effects*,  metabolism,  physiopathology
Nitric Oxide Donors / pharmacology
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Prostaglandins / pharmacology
Rats, Wistar
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Prostaglandins; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 50-78-2/Aspirin; 51-84-3/Acetylcholine; 59-42-7/Phenylephrine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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