| Dietary G-rutin suppresses glycation in tissue proteins of streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 14577587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study focused on examining the efficacy of feeding a rutin-glucose derivative (G-rutin) to inhibit glycation reactions that can occur in muscle, kidney and plasma proteins of diabetic rats. Both thiobarbituric acid-reactive substance levels and protein carbonyl contents in muscle and kidney were significantly (p < 0.05) reduced in streptozotocin-induced diabetic rats fed G-rutin supplemented diet, compared to diabetic rats fed control diet. The N(epsilon)-fructoselysine content in muscle and kidney, a biomarker of early glycation reaction, was markedly (p < 0.05) increased by diabetes, but significantly (p < 0.05) reduced in diabetic rats fed G-rutin. Advanced glycation end-products (AGEs) in serum and kidney protein were measured by immunoblot using anti-AGE antibody, and were also reduced in diabetic rats fed dietary G-rutin. Feeding G-rutin also slightly inhibited aldose reductase activity in these animals. These results demonstrate for the first time that dietary G-rutin consumption can provide potential health benefits that are related to the inhibition of tissue glycation reactions common to diabetes. |
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Authors:
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Takashi Nagasawa; Nobuaki Tabata; Yoshiaki Ito; Youichi Aiba; Naoyuki Nishizawa; David D Kitts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 252 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-27 Completed Date: 2004-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 141-7 Citation Subset: IM |
Affiliation:
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Food and Health Science, Faculty of Agriculture, Iwate University, Morioka, Iwate, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Diabetes Mellitus, Experimental / metabolism* Diet* Glucose / metabolism* Glycosylation End Products, Advanced Lysine / analogs & derivatives*, blood, metabolism Male Rats Rats, Wistar Rutin / administration & dosage, pharmacology* Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Glycosylation End Products, Advanced; 153-18-4/Rutin; 18883-66-4/Streptozocin; 21291-40-7/fructosyl-lysine; 50-99-7/Glucose; 56-87-1/Lysine |
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