| Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD. | |
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MedLine Citation:
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PMID: 19959720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal disease leads to perturbations in calcium and phosphate homeostasis and vitamin D metabolism. Dietary fructose aggravates chronic kidney disease (CKD), but whether it also worsens CKD-induced derangements in calcium and phosphate homeostasis is unknown. Here, we fed rats diets containing 60% glucose or fructose for 1 mo beginning 6 wk after 5/6 nephrectomy or sham operation. Nephrectomized rats had markedly greater kidney weight, blood urea nitrogen, and serum levels of creatinine, phosphate, and calcium-phosphate product; dietary fructose significantly exacerbated all of these outcomes. Expression and activity of intestinal phosphate transporter, which did not change after nephrectomy or dietary fructose, did not correlate with hyperphosphatemia in 5/6-nephrectomized rats. Intestinal transport of calcium, however, decreased with dietary fructose, probably because of fructose-mediated downregulation of calbindin 9k. Serum calcium levels, however, were unaffected by nephrectomy and diet. Finally, only 5/6-nephrectomized rats that received dietary fructose demonstrated marked reductions in 25-hydroxyvitamin D(3) and 1,25-dihydroxyvitamin D(3) levels, despite upregulation of 1alpha-hydroxylase. In summary, excess dietary fructose inhibits intestinal calcium absorption, induces marked vitamin D insufficiency in CKD, and exacerbates other classical symptoms of the disease. Future studies should evaluate the relevance of monitoring fructose consumption in patients with CKD. |
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Authors:
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Veronique Douard; Abbas Asgerally; Yves Sabbagh; Shozo Sugiura; Sue A Shapses; Donatella Casirola; Ronaldo P Ferraris |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-12-03 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 21 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-03-16 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 261-71 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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metabolism Animals Bone Density Calcifediol / metabolism Calcitriol / metabolism Calcium / metabolism* Chronic Disease Dietary Carbohydrates / adverse effects, pharmacology* Disease Models, Animal Fructose / adverse effects, pharmacology* Glucose / pharmacology Intestinal Absorption / drug effects* Kidney / metabolism, surgery Kidney Diseases / complications, metabolism* Male Nephrectomy Phosphates / metabolism Rats Rats, Sprague-Dawley Vitamin D Deficiency / etiology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AG-12161/AG/NIA NIH HHS; DK075617/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Phosphates; 19356-17-3/Calcifediol; 30237-26-4/Fructose; 32222-06-3/Calcitriol; 50-99-7/Glucose; 7440-70-2/Calcium; EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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