| Dietary fructose and hypertension. | |
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MedLine Citation:
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PMID: 20957458 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The association between fructose and increased blood pressure is still incompletely defined, because experimental studies have produced dissimilar conclusions. Amplified vasopressor responses to minimal stimuli and differing responses to fructose in peripheral versus central sites may explain the controversy. Fructose induces systemic hypertension through several mechanisms mainly associated with deleterious effects on target organs (kidney, endothelium, heart) exerted by the byproducts of its metabolism, such as uric acid. The kidney is particularly sensitive to the effects of fructose because high loads of this sugar reach renal tissue. In addition, fructose increases reabsorption of salt and water in the small intestine and kidney; thus the combination of salt and fructose has a synergistic effect in the development of hypertension. Clinical and epidemiologic studies have also linked fructose consumption with hypertension. Further studies are warranted in order to understand the role of fructose in the development of hypertension. |
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Authors:
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Magdalena Madero; Santos E Perez-Pozo; Diana Jalal; Richard J Johnson; Laura G Sánchez-Lozada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current hypertension reports Volume: 13 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Affiliation:
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Department of Nephrology, INC Ignacio Chávez, Juan Badiano 1, Mexico City, Mexico. madero.magdalena@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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