Document Detail

Dietary DHA: time course of tissue uptake and effects on cytokine secretion in mice.
MedLine Citation:
PMID:  20487585     Owner:  NLM     Status:  MEDLINE    
Consumption of DHA has numerous beneficial effects, but little is known about these effects during the first few days of the DHA dietary intake. The main objectives of the present study were to determine the time course of DHA incorporation into phospholipids in different mouse tissues and the effects of DHA supplementation on adiponectin and leptin secretion. Mice were fed either a control diet or a DHA-rich diet, and some were killed on days 0, 4, 8, 16 and 32. Some mice were fed the DHA-rich diet for 16 d, and were then maintained on the control diet for sixteen more days (washout period). DHA supplementation increased plasma adiponectin secretion by 2·4-fold as early as 4 d after the initiation of the DHA-rich diet feeding. The adiponectin concentration remained 1·6-fold higher after the 16 d washout period. Plasma leptin levels were significantly lower after 4 d of feeding with DHA. These effects were associated with a significant increase in DHA incorporation in phosphatidylethanolamine and phosphatidylcholine of all analysed tissues (liver, heart and white adipose tissues). DHA mainly got incorporated at the expense of n-6 arachidonic acid. The present data show that DHA rapidly improved the profile of secreted adipokines, and that these protective effects were long lasting.
Jennifer Lefils; Alain Géloën; Hubert Vidal; Michel Lagarde; Nathalie Bernoud-Hubac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-21
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1304-12     Citation Subset:  IM    
Université de Lyon, UMR 870 INSERM, Insa-Lyon (RMND-IMBL), Univ Lyon 1, Inra 1235, Hospices Civils de Lyon, F-69621 Villeurbanne, France.
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MeSH Terms
Adiponectin / blood,  secretion*
Adipose Tissue, White / metabolism
Arachidonic Acid / metabolism
Cytokines / secretion
Dietary Supplements*
Docosahexaenoic Acids / pharmacokinetics*,  pharmacology*
Leptin / blood,  secretion*
Liver / metabolism*
Mice, Inbred ICR
Myocardium / metabolism
Phosphatidylcholines / metabolism*
Phosphatidylethanolamines / metabolism
Time Factors
Tissue Distribution
Reg. No./Substance:
0/Adiponectin; 0/Cytokines; 0/Leptin; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 25167-62-8/Docosahexaenoic Acids; 39382-08-6/phosphatidylethanolamine; 506-32-1/Arachidonic Acid

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